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Membrane proteins are responsible for many fundamental cellular processes including the transport of ions and metabolites, energy conversion, and signal transduction. They are the target of about two thirds of modern drugs. However, membrane proteins, especially large complexes, are challenging for structural studies and so are underrepresented in structural databases.
The Sazanov group has long been interested in the structural biology of membrane proteins. The main emphasis has been on complex I of the respiratory chain, a huge (~1 MDa) enzyme central to cellular energy production. So far, they have determined all the first atomic structures of complex I, from bacterial to the more elaborate mammalian version. The structures suggest a unique mechanism of proton translocation, which they are studying using both X-ray crystallography and cryo-electron microscopy. They are also investigating other related membrane protein complexes, such as antiporters. Their studies will help to understand the molecular design of some of the most intricate biological machines. Medical implications are multifaceted and the Sazanov group is interested in developing potential drug candidates.
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论文共 119 篇作者统计合作学者相似作者
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Biochimica et Biophysica Acta (BBA) - Bioenergetics (2024): 149119
Anton Kavaleuski,Leonid Sazanov
Biochimica et Biophysica Acta (BBA) - Bioenergetics (2024): 149306
Nature structural & molecular biology (2024)
The Biochemical journalno. 5 (2023): 319-333
Vladyslav Kravchuk, Olga Petrova,Domen Kampjut, Anna Wojciechowska-Bason, Zara Breese,Leonid Sazanov
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作者统计
#Papers: 124
#Citation: 8995
H-Index: 44
G-Index: 82
Sociability: 6
Diversity: 3
Activity: 52
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