Dr. Leiter has several research interests including clinical trials on the prevention of atherosclerosis, especially in diabetes, and the dietary and pharmacologic treatment of diabetes mellitus, hyperlipidemia, hypertension, and obesity. He has over 800 publications in peer-reviewed journals. He was an investigator in many of the landmark diabetes trials including the DCCT, ACCORD, and ADVANCE and has had leadership roles in many past and ongoing outcome trials in both the diabetes and lipid areas. In 2018, 2019, and 2020 he was a Clarivate Analytics Top 1% Highly Cited Researcher.