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个人简介
Dr. Sklar was recruited to New Mexico to lead the National Flow Cytometry Resource at Los Alamos and to develop a biotechnology research program at the University of New Mexico. From 1990-2002 he served as Director or Co-Director of the P41 National Flow Cytometry Resource at Los Alamos (P41RR01315) with responsibilities in research, collaboration, service, training, and dissemination. Beginning in 1998, Sklar led a team of colleagues in the development of high throughput flow cytometry for signal transduction and drug discovery.
This work began as an NIH-funded Bioengineering Research Partnership (BRP GM60799/EB00264), funded in the inaugural year of that NIH program and bringing together cell and molecular biology, biophysics, instrumentation hardware and software and microfluidics. This team was involved in discovery research that involved membrane steroid receptors of the G protein-coupled receptor (GPCR) class and has discovered small molecules that differentiate the classical nuclear estrogen receptors from the novel membrane estrogen receptors. The team has also developed real-time methods to examine affinity, avidity and conformation of integrin receptors involved in cell adhesion (R01 HL08162).
The team has continued evolving and innovating to use high throughput flow cytometry for small molecule discovery as an NIH Roadmap Molecular Libraries Screening Center (1U54MH074425) and then as a Probe Production Center (1U54MH084690). Continuing team innovation and evolution includes support for drug development, testing and formulation through the Chemical Biology Consortium of the NCI Experimental Therapeutics Program.
研究兴趣
论文共 458 篇作者统计合作学者相似作者
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DRUG DISCOVERY TODAYno. 5 (2024): 1-8
Journal of visualized experiments (2024)
crossref(2023)
Yuna Guo,S. Ray Kenney, Linda S. Cook,Sarah F. Adams,Teresa Rutledge,Elsa Romero,Tudor I. Oprea,Larry A. Sklar, Edward J. Bedrick,Charles L. Wiggins,Huining Kang,Lesley Lomo,Carolyn Y. Muller,Angela Wandinger-Ness, Laurie G. Hudson
openalex(2023)
crossref(2023)
crossref(2023)
crossref(2023)
crossref(2023)
Yuna Guo,S. Ray Kenney, Linda S. Cook,Sarah F. Adams,Teresa Rutledge,Elsa Romero,Tudor I. Oprea,Larry A. Sklar, Edward J. Bedrick,Charles L. Wiggins,Huining Kang,Lesley Lomo,Carolyn Y. Muller,Angela Wandinger-Ness, Laurie G. Hudson
openalex(2023)
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作者统计
#Papers: 456
#Citation: 22979
H-Index: 75
G-Index: 138
Sociability: 7
Diversity: 0
Activity: 1
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