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个人简介
Dr. Golub’s research focuses on mechanisms of collagen degradation including bone resorption during periodontal disease (and relevant medical disorders) particularly the role of tissue (“Host”)-derived matrix metalloproteinases, such as the collagenases (e.g., MMP-8) and gelatinases (e.g., MMP-9). In this regard, he was the 1st to develop government (USA, Canada, Europe)-approved MMP-inhibitor drugs for any disease, but particularly for periodontitis and the chronic inflammatory skin disease, rosacea. The same medications have also demonstrated clinical efficacy, and safety, in humans with other inflammatory-collagenolytic diseases such as arthritis, diabetes, cardiovascular disease, and cancer. The 1st generation medications are novel NON-antibiotic regimens of tetracyclines which function, at least in part, by binding calcium & zinc in the catalytic domain of these neutral proteinases. Second-generation medications being developed are bi-phenolic rather than tetra-phenolic, with a similar (even enhanced) cation-binding site, and are derived from novel chemical modifications of the natural spice curcumin. His research includes (but is not limited to) cell and tissue culture, in vivo studies using different animal models, and clinical trials.
研究兴趣
论文共 149 篇作者统计合作学者相似作者
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Frontiers in Dental Medicine (2024)
Chiara Gnocchi, Martina Lenzuni,Fabrizio Fiorentini, Danila Merino,Maria Summa,Lorne Golub,Hsi-Ming Lee,Francis Johnson,Rosalia Bertorelli,Giulia Suarato, Athanassia Athanassiou
Journal of Drug Delivery Science and Technologypp.106155, (2024)
Drugs and Drug Candidatesno. 4 (2023): 810-826
Scientific reportsno. 1 (2023)
Frontiers in dental medicine (2021)
AMERICAN JOURNAL OF DENTISTRYno. 2 (2021): 97-100
引用1浏览0WOS引用
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JOURNAL OF INFLAMMATION RESEARCH (2021): 5337-5347
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作者统计
#Papers: 149
#Citation: 6953
H-Index: 51
G-Index: 76
Sociability: 6
Diversity: 0
Activity: 1
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