基本信息
浏览量:79
职业迁徙
个人简介
Current research areas include how nutrients in the diets of western populations which are at high risk for colon cancer alter pathways that perturb intestinal homeostasis, and in particular, modulation by calcium and vitamin D3 intake (Augenlicht, Velcich, Klampfer); the role of Notch signaling, and its interaction with other pathways such as Wnt, ras and Klf4 signaling, in cell maturation, lineage specific differentiation and tumor formation (Augenlicht, Velcich, Klampfer); the role of epigenetic mechanisms such as DNA methylation, histone and other nuclear protein acetylation, and transcriptional pausing in the normal maturation of intestinal epithelial cells and alterations that lead to cancer (Mariadason, Velcich, Klampfer, Augenlicht); identification and mechanisms of predictive markers of drug response (Mariadason); and the role of the mitochondrial membrane potential in regulating cell phenotype (Heerdt).
A major intersection of interests in the group is the role of inflammation in colon tumor development and progression. In multiple mouse dietary and genetic models of intestinal cancer developed by Augenlicht, Velcich, and Lin, inflammation is associated with tumor development, perhaps linked to altered intestinal microbial populations. Recent experiments by Klampfer and by Lin have identified signals from the macrophage to epithelial cells as important in disruption of mucosal homeostasis and epithelial growth regulation. The mechanisms that cause the inflammation, the role of the inflammatory response in tumorigenesis, and its modulation of inflammation by nutrients and pharmacological agents are under investigation.
A major intersection of interests in the group is the role of inflammation in colon tumor development and progression. In multiple mouse dietary and genetic models of intestinal cancer developed by Augenlicht, Velcich, and Lin, inflammation is associated with tumor development, perhaps linked to altered intestinal microbial populations. Recent experiments by Klampfer and by Lin have identified signals from the macrophage to epithelial cells as important in disruption of mucosal homeostasis and epithelial growth regulation. The mechanisms that cause the inflammation, the role of the inflammatory response in tumorigenesis, and its modulation of inflammation by nutrients and pharmacological agents are under investigation.
研究兴趣
论文共 258 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
EXPERIMENTAL AND MOLECULAR MEDICINEno. 3 (2024): 1-6
Experimental and Molecular Medicine/Experimental and molecular medicineno. 3 (2024): 495-500
Mathijs P. Verhagen,Rosalie Joosten,Mark Schmitt, Niko Vaelimaeki,Andrea Sacchetti,Kristiina Rajamaeki,Jiahn Choi, Paola Procopio,Sara Silva,Berdine van der Steen,Thierry P. P. van den Bosch,Danielle Seinstra, Annemarie C. de Vries,Michail Doukas,Leonard H. Augenlicht,Lauri A. Aaltonen,Riccardo Fodde
Nature genetics (2024)
crossref(2023)
crossref(2023)
crossref(2023)
bioRxiv the preprint server for biology (2023)
crossref(2023)
crossref(2023)
加载更多
作者统计
#Papers: 261
#Citation: 13066
H-Index: 64
G-Index: 109
Sociability: 7
Diversity: 0
Activity: 2
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn