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Despite major advances in the fields of microbial pathogenesis and medicinal chemistry, only 2 new chemical classes of antibiotics have been approved in the past 20 years. Some infections that were once predictably curable have become more difficult, if not impossible to treat, and resistance to every antibiotic in clinical use, a growing reality. Antibiotic development has thus re-emerged as a major area of unmet medical need.
Among current infectious diseases, the need for new antibiotics is nowhere more evident than for TB. TB is the leading bacterial cause of deaths worldwide, leading cause of deaths in the HIV-positive population, and leading cause of death from a curable infection. It is thus somewhat surprising that control of the pandemic remains hindered by a lack of rapid cures. Current TB chemotherapies are longer and more complex than for virtually any other bacterial infection. As a result, these once therapeutic miracles have given way to rates of treatment non-compliance and failure sufficient to allow continued transmission and promote the paradoxical emergence of multidrug- (MDR) and extensively drug resistant (XDR) disease.
Our lab seeks to address both of these shortfalls by applying metabolomic technologies to elucidate the intracellular biochemistry of Mtb and its response to perturbation by host relevant stresses and antimycobacterial compounds.
Among current infectious diseases, the need for new antibiotics is nowhere more evident than for TB. TB is the leading bacterial cause of deaths worldwide, leading cause of deaths in the HIV-positive population, and leading cause of death from a curable infection. It is thus somewhat surprising that control of the pandemic remains hindered by a lack of rapid cures. Current TB chemotherapies are longer and more complex than for virtually any other bacterial infection. As a result, these once therapeutic miracles have given way to rates of treatment non-compliance and failure sufficient to allow continued transmission and promote the paradoxical emergence of multidrug- (MDR) and extensively drug resistant (XDR) disease.
Our lab seeks to address both of these shortfalls by applying metabolomic technologies to elucidate the intracellular biochemistry of Mtb and its response to perturbation by host relevant stresses and antimycobacterial compounds.
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论文共 211 篇作者统计合作学者相似作者
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biorxiv(2024)
Peiyu Xu, Shenni Liang, Andrew Hahn, Vivian Zhao, Wai Tung 'Jack' Lo,Benjamin C Haller,Benjamin Sobkowiak,Melanie H Chitwood,Caroline Colijn,Ted Cohen,Kyu Y Rhee,Philipp W Messer,Martin T Wells,Andrew G Clark,Jaehee Kim
bioRxiv : the preprint server for biology (2024)
Amrita Singh,Samantha Ottavi,Inna Krieger,Kyle Planck,Andrew Perkowski,Takushi Kaneko, Andrew M. Davis, Christine Suh, David Zhang,Laurent Goullieux,Alexander Alex,Christine Roubert,Mark Gardner,Marian Preston,Dave M. Smith,Yan Ling,Julia Roberts,Bastien Cautain,Anna Upton,Christopher B. Cooper,Natalya Serbina, Zaid Tanvir,John Mosior,Ouathek Ouerfelli,Guangli Yang,Ben S. Gold,Kyu Y. Rhee,James C. Sacchettini,Nader Fotouhi,Jeffrey Aube,Carl Nathan
Cara Adolph,Chen-Yi Cheung,Matthew B. McNeil,William J. Jowsey,Zoe C. Williams,Kiel Hards,Liam K. Harold,Ashraf Aboelela,Richard S. Bujaroski,Benjamin J. Buckley,Joel D. A. Tyndall,Zhengqiu Li,Julian D. Langer,Laura Preiss,Thomas Meier,Adrie J. C. Steyn,Kyu Y. Rhee,Michael Berney,Michael J. Kelso,Gregory M. Cook
CELL CHEMICAL BIOLOGYno. 4 (2024)
Lauren C LaMonica, Jingwei Ren, Nina Jain, Eli S Goldberg,Kyu B Rhee, Paige Wickner,Sreekanth K Chaguturu
The American journal of managed careno. 3 (2024): e73-e77
bioRxiv : the preprint server for biology (2024)
Nature communicationsno. 1 (2024)
Adrian Jinich,Sakila Z. Nazia,Andrea V. Tellez, Amy M. Wu, Ricardo Almada-Monter,Clare M. Smith,Kyu Rhee
biorxiv(2024)
Candice R. Gurbatri,Georgette A. Radford,Laura Vrbanac,Jongwon Im,Elaine M. Thomas,Courtney Coker, Samuel R. Taylor,YoungUk Jang, Ayelet Sivan,Kyu Rhee, Anas A. Saleh,Tiffany Chien,Fereshteh Zandkarimi,Ioana Lia,Tamsin R. M. Lannagan,Tongtong Wang,Josephine A. Wright,Hiroki Kobayashi,Jia Q. Ng,Matt Lawrence,Tarik Sammour,Michelle Thomas,Mark Lewis,Lito Papanicolas,Joanne Perry,Tracy Fitzsimmons,Patricia Kaazan,Amanda Lim, Alexandra M. Stavropoulos, Dion A. Gouskos,Julie Marker,Cheri Ostroff,Geraint Rogers,Nicholas Arpaia,Daniel L. Worthley,Susan L. Woods,Tal Danino
JCI insightno. 10 (2024)
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作者统计
#Papers: 212
#Citation: 8181
H-Index: 48
G-Index: 86
Sociability: 7
Diversity: 0
Activity: 3
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