Dr. Albertine's research topic is acute and chronic lung disease, with emphasis on neonatal chronic lung disease. The focus of his studies is identification of molecular mechanisms that disrupt lung development in the preterm neonate who requires prolonged mechanical ventilation. Current studies are testing hypotheses about the effect of preterm birth and prolonged mechanical ventilation on retinoid signaling pathways, vascular growth factor signaling pathways, cell turnover signaling pathways, and surfactant apoprotein signaling pathways. While the primary focus is on the responses in the lung, concurrent studies are comparing the molecular effects in other organs, notably the brain, liver, and intestine. New studies are testing the hypothesis that preterm birth and prolonged mechanical ventilation change epigenetic determinants of regulation of gene expression. Dr. Albertine's research program has been NIH-funded since 1980.

Research Interests
Bronchopulmonary Dysplasia
Epigenetics
Neonatal Chronic Lung Disease
Lung Development
Co-Morbidities of BPD
Brain Injury on Neonatal Chronic Lung Disease
Gut Injury in Neonatal Chronic Lung Disease
Kidney Injury in Neonatal Chronic Lung Disease
Brain Development
Kidney Development
Neurodevelopmental Impairment