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职业迁徙
个人简介
I did my masters in Biotechnology from Choudhary Charan Singh University, Meerut and Ph.D. from Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India. My Ph.D. thesis research was on liver-specific microRNA-122 (miR-122) and hepatitis C virus infection. I studied several aspects of miR-122 in relation to hepatitis C - i) expression of circulating miR-122 in Hepatitis C patients’ serum and its correlation with disease severity, ii) role of miR-122 in hepatitis C virus (HCV) replication and propagation using in vitro cell culture system, iii) role of miR-122 in hepatocellular and tumor suppression. MicroRNAs (MiRNAs) are the class of small non-coding RNA molecules regulating gene expression by binding with the 3’-UTR of their specific target mRNAs and implicated in various human diseases including cancer, cardiovascular diseases, liver diseases, viral infection, diabetes and in neurodegenerative disorders. MiRNAs also participate in inter-and-intracellular communication and are transported from cells/tissues to the extracellular spaces and bio-fluids. In the diseased state, endogenous levels of miRNAs change in disease-infected tissues and occasionally are released into the peripheral system. My long-term goal is to build up my research carrier in miRNA biology and to understand the biomarker and therapeutic impacts of miRNAs in human diseases.
I joined Dr. Reddy’s lab as a postdoctoral research associate in 2015. Dr. Reddy’s lab is working on several aspects of Alzheimer’s disease (AD) such as APP processing, Aβ pathology, Tau/p-Tau pathology, synaptic dysfunction, mitochondrial biogenesis, mitochondrial dynamics, and mouse models of aging and neurodegenerative diseases. In Dr. Reddy’s lab, my research project was to investigate the peripheral circulating miRNAs as biomarkers for AD. We performed the global Affymetrix microarray analysis of serum samples collected from AD patients, Mild cognitive impairment individuals (MCI) and healthy controls. We identified several miRNAs which were deregulated in AD vs MCI vs healthy subjects. Our careful validation analysis of potential miRNAs on large number of AD serum samples, AD postmortem brains, AD Fibroblasts, AD B-lymphocytes, AD mouse model (Tg2576) and AD cell lines identified microRNA-455-3p (miR-455-3p) as potential biomarker for AD. Our lab was the first to discover the role of miR-455-3p in AD. Further, we investigated the molecular mechanism of miR-455-3p in AD progression and pathogenesis. We unveiled the protective role of miR-455-3p in APP processing, Aβ pathology, mitochondrial biogenesis, mitochondrial dynamics and synaptic activity.
研究兴趣
论文共 48 篇作者统计合作学者相似作者
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Neuroscience insights (2024): 26331055241254846-26331055241254846
Ageing Research Reviewspp.102377, (2024)
Elsevier eBookspp.91-108, (2023)
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FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2023)
Elsevier eBookspp.109-122, (2023)
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Ageing Research Reviews (2023)
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作者统计
#Papers: 48
#Citation: 1653
H-Index: 18
G-Index: 32
Sociability: 5
Diversity: 3
Activity: 30
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