基本信息
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Career Trajectory
Bio
Dr K. M. CHAN graduated with BSc and received his PhD at the Department of Biochemistry, HKU. He then moved to Mayo Clinic (Rochester MN, USA) for postdoctoral training and obtained the Edward C. Kendall Research Fellowship in Biochemistry before rejoining HKU as Research Assistant Professor in June 2013. In February 2015 he joined the Department of Biomedical Sciences (BMS), City University of Hong Kong as a tenure-track Assistant Professor.
Research Interests
Dr Chan is interested in understanding 1) the role of epigenetics in regulating gene expression and human diseases and 2) how epigenetic information in maintained during cell division. It is well known that genetic information is encoded by the DNA sequence. However, DNA alone does not account for the complexity of the mammalian genome. Chromatin, comprising DNA, core histones and other regulatory proteins, regulates gene expression and maintains genome stability. Recent studies including ours have used the next generation sequencing technologies and the CRISPR-Cas9 approach to elucidate the mechanisms of mutant histones in the development of brain and bone cancers. We are currently focusing on identifying new cancer driving histone mutations and discovering therapeutics for these diseases using different animal models.
Research Interests
Dr Chan is interested in understanding 1) the role of epigenetics in regulating gene expression and human diseases and 2) how epigenetic information in maintained during cell division. It is well known that genetic information is encoded by the DNA sequence. However, DNA alone does not account for the complexity of the mammalian genome. Chromatin, comprising DNA, core histones and other regulatory proteins, regulates gene expression and maintains genome stability. Recent studies including ours have used the next generation sequencing technologies and the CRISPR-Cas9 approach to elucidate the mechanisms of mutant histones in the development of brain and bone cancers. We are currently focusing on identifying new cancer driving histone mutations and discovering therapeutics for these diseases using different animal models.
Research Interests
Papers共 49 篇Author StatisticsCo-AuthorSimilar Experts
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International journal of molecular sciencesno. 6 (2024)
Huiqi Tan, Mia Xinfang Miao, Rylee Xu Luo,Joan So,Lei Peng,Xiaoxuan Zhu,Eva Hin Wa Leung,Lina Zhu,Kui Ming Chan,Martin Cheung,Siu Yuen Chan
NATURE COMMUNICATIONSno. 1 (2024)
International journal of molecular sciencesno. 17 (2024)
BMC Biologyno. 1 (2024)
Qingling He, Jianyang Hu, Hao Huang,Tan Wu, Wenxiu Li, Saravanan Ramakrishnan, Yilin Pan,Kui Ming Chan,Liang Zhang, Mengsu Yang,Xin Wang, Y. Rebecca Chin
Epigenetics & Chromatinno. 1 (2024): 1-14
10th International Conference on Higher Education Advances (HEAd’24) (2024)
Haiyun Gan, Xing Kang,Xinran Li,Jiaqi Zhou,Yang Zhang,Suili Hu, Zhiwen Deng, Yuchun Wu, Nan Wang, Yajing Xu,Liangming Chen, Jinyi Chen, Zhen Yue,Yuan Yao, Xinran Yang,Sitong Yao,Congcong Tian,Qing Wen, Xiaoyan Liang, Lixia Yan, Olivia M Depies,Kui ming Chan,Xiaohuan Liang,Junbiao Dai,Zhiquan Wang,Chuanhe Yu, Gang Li,Xiangyu Liu
crossref(2024)
Congcong Tian, Qin Zhang, Jing Jia,Jiaqi Zhou,Ziwei Zhang,Srinivasu Karri, Jiuhang Jiang,Quinn Dickinson,Yuan Yao, Xiaorong Tang, Yuxin Huang, Ting Guo, Ziwei He,Zheng Liu,Yuan Gao, Xinran Yang, Yuchun Wu,Kui Ming Chan,Daoqin Zhang,Junhong Han,Chuanhe Yu,Haiyun Gan
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICAno. 20 (2024)
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Author Statistics
#Papers: 50
#Citation: 2593
H-Index: 21
G-Index: 35
Sociability: 6
Diversity: 2
Activity: 110
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