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个人简介
Research InterestsChatterjee
Our principal research interests are in genetic and molecular endocrinology, with particular emphasis on disorders nuclear hormone synthesis and action. We study several human disorders: Resistance to Thyroid Hormone (RTH), defined broadly as abnormal circulating thyroid hormones with tissue refractoriness to hormone action; and PPARgamma gene defects associated with lipodystrophic insulin resistance. Candidate gene and whole exome approaches are used to identify novel genetic aetiologies mediating defective hormone action. Human phenotypic studies elucidate mechanisms whereby thyroid hormones alter physiological processes acting via receptor subtypes in tissues. In a multisystem selenoprotein deficiency disorder including thyroid deiodinase enzymes, we are investigating features (cardiovascular, metabolic, photosensitivity) attributable to elevated ROS and the roles of selenoproteins of unknown function. Finally, we translate our research into technologies (biochemical, genetic) that comprise our national diagnostic laboratory service, develop biomarkers of hormone action and trial therapies (e.g. selective thyromimetics) that are applicable to commoner thyroid dysfunction or metabolic disorders.
Our principal research interests are in genetic and molecular endocrinology, with particular emphasis on disorders nuclear hormone synthesis and action. We study several human disorders: Resistance to Thyroid Hormone (RTH), defined broadly as abnormal circulating thyroid hormones with tissue refractoriness to hormone action; and PPARgamma gene defects associated with lipodystrophic insulin resistance. Candidate gene and whole exome approaches are used to identify novel genetic aetiologies mediating defective hormone action. Human phenotypic studies elucidate mechanisms whereby thyroid hormones alter physiological processes acting via receptor subtypes in tissues. In a multisystem selenoprotein deficiency disorder including thyroid deiodinase enzymes, we are investigating features (cardiovascular, metabolic, photosensitivity) attributable to elevated ROS and the roles of selenoproteins of unknown function. Finally, we translate our research into technologies (biochemical, genetic) that comprise our national diagnostic laboratory service, develop biomarkers of hormone action and trial therapies (e.g. selective thyromimetics) that are applicable to commoner thyroid dysfunction or metabolic disorders.
研究兴趣
论文共 311 篇作者统计合作学者相似作者
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Maura Agostini, Reza Maroofian,Annarita Nappi, Karimiani Ehsan Ghayoor, Torbati Paria Najarzadeh, Greta Lyons, Justin Cross,Carla Moran,Monica Dentice,Krishna Chatterjee
Endocrine Abstracts (2024)
PloS oneno. 8 (2024): e0306538-e0306538
European Thyroid Journalno. 4 (2024): 1-22
Endocrine Abstracts (2024)
Carla Moran,Faraneh Vargha‐Khadem,Chris Clark,Kiran K. Seunarine, Francesco Muntoni, Richard A. I. Bethlehem,Keith Lindley,Laura Watson,Greta Lyons,Mehul Dattani,Krishna Chatterjee
Endocrine abstracts (2023)
Riccardo Dore,Laura Watson,Stefanie Hollidge,Christin Krause,Sarah Christine Sentis,Rebecca Oelkrug,Cathleen Geißler,Kornelia Johann,Mehdi Pedaran,Greta Lyons,Nuria Lopez-Alcantara,Julia Resch,Friedhelm Sayk,Karl Alexander Iwen,Andre Franke, Teide Jens Boysen,Jeffrey W. Dalley,Kristina Lorenz,Carla Moran,Kirsten L. Rennie,Anders Arner,Henriette Kirchner,Krishna Chatterjee,Jens Mittag
Nature communicationsno. 1 (2023): 3312-11
Riccardo Dore,Laura Watson,Stefanie Hollidge,Christin Krause,Sarah Christine Sentis,Rebecca Oelkrug, Cathleen Geisser,Kornelia Johann,Mehdi Pedaran,Greta Lyons,Nuria Lopez-Alcantara,Julia Resch,Friedhelm Sayk,Karl Alexander Iwen,Andre Franke, Teide Jens Boysen,Jeffrey W. Dalley,Kristina Lorenz,Carla Moran,Kirsten L. Rennie,Anders Arner,Henriette Kirchner,Krishna Chatterjee,Jens Mittag
NATURE COMMUNICATIONSno. 1 (2023)
Erik Schoenmakers,Federica Marelli,Helle F. Jørgensen,W. Edward Visser,Carla Moran,Stefan Groeneweg, Carolina Avalos,Sean J. Jurgens,Nichola Figg,Alison Finigan,Neha Wali,Maura Agostini,Hannah Wardle-Jones,Greta Lyons,Rosemary Rusk,Deepa Gopalan, Philip Twiss,Jacob J. Visser,Martin Goddard,Samer A. M. Nashef,Robin Heijmen,Paul Clift,Sanjay Sinha,James P. Pirruccello,Patrick T. Ellinor,Elisabeth M. Busch-Nentwich,Ramiro Ramirez-Solis,Michael P. Murphy,Luca Persani,Martin Bennett,Krishna Chatterjee
NATURE COMMUNICATIONSno. 1 (2023)
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作者统计
#Papers: 311
#Citation: 20933
H-Index: 71
G-Index: 141
Sociability: 8
Diversity: 3
Activity: 107
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