Dr. McMasters’ current clinical areas of interest are melanoma and cutaneous malignancies, breast cancer, and sarcoma. In his role as the Director of the Multidisciplinary Melanoma Clinic, he works with Dr. Jason Chesney and others to identify the most effective combination of therapeutic modalities including surgery, immunotherapy, targeted therapies, and radiation therapy for patients with all stages of melanoma.
Throughout his career, Dr. McMasters has directed a basic and translational science laboratory studying adenovirus-mediated cancer gene therapy, melanoma biomarkers, and more recently immunotherapy, which has been funded by the National Institutes of Health, the Department of Defense, the American Cancer Society, the Melanoma Research Foundation, and other agencies. He is the author and principal investigator of the Sunbelt Melanoma Trial, a multi-institutional study involving over 3500 patients from 79 institutions across North America. He is also the principal investigator of the University of Louisville Breast Sentinel Lymph Node Study, a multi-institutional study involving more than 300 surgeons and 4,100 patients. He has also been principal investigator of or co-investigator of dozens of clinical trials. Dr. McMasters has been President of the Society of Surgical Oncology, the Society of Surgical Chairs, the Southern Surgical Association, the Western Surgical Association, and the Southeastern Surgical Association. He is the current Treasurer of the American Surgical Association. He has served as Editor-in-Chief of Annals of Surgical Oncology since 2018. He serves as a Councilor of the American Board of Surgery and a member of the Complex General Surgical Oncology Board. He has authored more than 500 peer-reviewed publications that have been cited more than 41,000 times, 29 book chapters, and a book entitled Hepatocellular Carcinoma: Targeted Therapy.