The Khokha lab studies tumour microenvironment and adult stem cell niches.

A major interest is to understand the molecular basis of breast cancer. To this end, our lab is elucidating the determinants of adult mammary stem cell pools and their regulation by ovarian hormones, with an emphasis on the deciphering the role of progesterone.

Our program is active in developing genetically engineered mouse models for human cancers, and novel tools for cancer gene discovery.