基本信息
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Career Trajectory
Bio
Dunker's area of expertise involves understanding intrinsically disordered proteins using bioinformatics approaches and laboratory experiments. His research in computational biology and bioinformatics began in the mid-1980's. In the mid-1990's, he used bioinformatics to study intrinsically disordered proteins. He and his collaborators were the first to consider these proteins as a distinct class with important biological functions. His bioinformatics research goals over the next several years included the improvement of intrinsic disorder predictions, especially with respect to identifying different types of disorder (flavors) and then to understanding the relationships between the different types of disorder and protein function, i.e., to understand flavor-function relationships. In addition, he wants to combine bioinformatics prediction with laboratory experimentation to develop new approaches for understanding protein-protein and protein-nucleic acid signaling interactions that involve intrinsically disordered proteins. Ongoing work suggests that the original proteins on earth were intrinsically disordered and that protein evolution followed a disorder to order pathway.
Research Interests
Papers共 454 篇Author StatisticsCo-AuthorSimilar Experts
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International Journal of Molecular Sciencesno. 14 (2024): 7537
Biomoleculesno. 6 (2023): 1015
Zenodo (CERN European Organization for Nuclear Research) (2022)
Lolita Piersimoni, Marina Abd El Malek,Twinkle Bhatia,Julian Bender, Christin Brankatschk,Jaime Calvo Sánchez,Guy W Dayhoff,Alessio Di Ianni, Jhonny Oscar Figueroa Parra, Dailen Garcia-Martinez,Julia Hesselbarth,Janett Köppen,Luca M Lauth, Laurin Lippik,Lisa Machner,Shubhra Sachan,Lisa Schmidt, Robin Selle,Ioannis Skalidis, Oleksandr Sorokin,Daniele Ubbiali,Bruno Voigt,Alice Wedler,Alan An Jung Wei, Peter Zorn,Alan Keith Dunker,Marcel Köhn,Andrea Sinz,Vladimir N Uversky
Journal of proteome researchno. 4 (2022): 874-890
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Author Statistics
#Papers: 466
#Citation: 91626
H-Index: 117
G-Index: 302
Sociability: 7
Diversity: 3
Activity: 16
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