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个人简介
The Giacomini research group focuses on expanding our understanding of membrane transporters. Membrane transporters are of great pharmacological importance, as they play a major role in drug efficacy by regulating drug disposition and distribution. Major questions addressed in the laboratory include: What is the in vivo role of membrane transporters in drug disposition and response? How does genetic variation in membrane transporters affect clinical drug response? What is the endogenous role of membrane transporters? And, what are the structural determinants of specificity?
As PI of the NIH-funded Pharmacogenomics of Membrane Transporters project, Dr. Kathy Giacomini is leading an effort to determine the clinical implications of specific genetic variants in over 100 membrane transporters. Project ventures, ranging from basic discovery to clinical studies, have demonstrated that common variants of membrane transporters contribute to differences in drug response in ethnically diverse populations. Ultimately, these studies will increase our knowledge of the genetic basis underlying drug response, and will contribute to advancing the era of personalized medicine. Furthermore, our studies will elucidate the genetic mechanisms of decreased drug response and, ultimately, contribute to improving drug design for safe and effective treatments of subgroups of patients who do not respond to standard treatments.
Research in the laboratory focuses on drugs used in the treatment of diseases associated with metabolic syndrome. We are particularly interested in two key therapeutic agents, allopurinol, first-line medical therapy for gout and high uric acid levels, and the anti-diabetic drug, metformin, one of the world’s most widely prescribed drugs. In particular, our research focuses on discovering functional genetic variants that underlie variation in response to these drugs in large ethnically diverse patient populations. As a co-leader of the international MetGen consortium with over 10,000 patients from Europe and the U.S. on metformin, Giacomini and her collaborators are seeking to discover genetic factors that contribute to poor response to metformin. Importantly, her group is interested in understanding the molecular mechanisms responsible for metformin’s pharmacologic action. For allopurinol, we have discovered that genetic variants in membrane transporters contribute to variation in response to allopurinol. We are now seeking to understand the mechanisms through which the variants act on allopurinol response.
Finally, Kathy Giacomini and her collaborator, Russ Altman of Stanford University are the Co-PIs of the UCSF–Stanford Center of Excellence in Regulatory Sciences and Innovation (CERSI) funded by the Food and Drug Administration (FDA). Established in 2014, the UCSF-Stanford CERSI aims to advance the field of regulatory sciences and improve the development and evaluation of diagnostics, therapeutics and medical devices. The UCSF-Stanford CERSI is the first FDA funded CERSI on the west coast and seeks to address key challenges related to education and research that will advance the discovery and development of medical products.
研究兴趣
论文共 533 篇作者统计合作学者相似作者
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CLINICAL PHARMACOLOGY & THERAPEUTICS (2024): S13-S13
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Dina Buitrago Silva,Marena Trinidad,Alicia Ljungdahl,Jezrael L. Revalde,Geoffrey Y. Berguig,William Wallace, Cory S. Patrick,Lorenzo Bomba,Michelle Arkin,Shan Dong,Karol Estrada,Keino Hutchinson,Jonathan H. Lebowitz,Avner Schlessinger,Katrine M. Johannesen,Rikke S. Moller,Kathleen M. Giacomini,Steven Froelich,Stephan J. Sanders,Arthur Wuster
The American Journal of Human Geneticsno. 6 (2024): 1222-1238
A. Riselli,S. Yee, K. Trumbach, C. Brett, J. Chun, X. Liang, R. Liu, R. Huo, W. Chen, Y. Xue, L. Zhang, X. Yang, Y. Lai,H. Shen, Q. Liu, S. Huang,K. Giacomini
CLINICAL PHARMACOLOGY & THERAPEUTICS (2024): S39-S39
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bioRxiv the preprint server for biology (2024)
American Journal of Pharmaceutical Educationno. 8 (2024): 100745-100745
Molecular Cellno. 10 (2024): 1932-1947.e10
Tanya J. Major,Riku Takei,Hirotaka Matsuo,Megan P. Leask,Nicholas A. Sumpter,Ruth K. Topless,Yuya Shirai,Wei Wang,Murray J. Cadzow,Amanda J. Phipps-Green,Zhiqiang Li,Aichang Ji,Marilyn E. Merriman, Emily Morice,Eric E. Kelley,Wen-Hua Wei,Sally P. A. McCormick,Matthew J. Bixley,Richard J. Reynolds,Kenneth G. Saag,Tayaza Fadason, Evgenia Golovina,Justin M. O'Sullivan,Lisa K. Stamp,Nicola Dalbeth, Abhishek,Michael Doherty,Edward Roddy,Lennart T. H. Jacobsson,Meliha C. Kapetanovic,Olle Melander,Mariano Andres,Fernando Perez-Ruiz,Rosa J. Torres,Timothy Radstake,Timothy L. Jansen,Matthijs Janssen,Leo A. B. Joosten,Ruiqi Liu,Orsolya I. Gaal,Tania O. Crisan,Simona Rednic,Fina Kurreeman,Tom W. J. Huizinga,Rene Toes,Frederic Liote,Pascal Richette,Thomas Bardin,Hang Korng Ea,Tristan Pascart,Geraldine M. McCarthy,Laura Helbert,Blanka Stiburkova, Anne-K. Tausche,Till Uhlig,Veronique Vitart,Thibaud S. Boutin,Caroline Hayward,Philip L. Riches,Stuart H. Ralston,Archie Campbell,Thomas M. MacDonald,Akiyoshi Nakayama,Tappei Takada,Masahiro Nakatochi,Seiko Shimizu,Yusuke Kawamura,Yu Toyoda,Hirofumi Nakaoka,Ken Yamamoto,Keitaro Matsuo,Nariyoshi Shinomiya,Kimiyoshi Ichida,Chaeyoung Lee,Linda A. Bradbury,Matthew A. Brown,Philip C. Robinson,Russell R. C. Buchanan,Catherine L. Hill,Susan Lester,Malcolm D. Smith,Maureen Rischmueller,Hyon K. Choi,Eli A. Stahl, Jeff N. Miner,Daniel H. Solomon,Jing Cui,Kathleen M. Giacomini,Deanna J. Brackman,Eric M. Jorgenson,Hongbo Liu,Katalin Susztak,Suyash Shringarpure,Alexander So,Yukinori Okada,Changgui Li,Yongyong Shi,Tony R. Merriman
NATURE GENETICSno. 11 (2024): 2392-+
Chetan P. Kulkarni, Jia Yang,Megan L. Koleske, Giovanni Lara,Khondoker Alam,Andre Raw,Bhagwant Rege,Liang Zhao,Dongmei Lu,Lei Zhang, Lawrence X. Yu,Robert A. Lionberger,Kathleen M. Giacomini,Deanna L. Kroetz,Sook Wah Yee
PHARMACEUTICSno. 5 (2024)
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作者统计
#Papers: 536
#Citation: 26123
H-Index: 82
G-Index: 147
Sociability: 7
Diversity: 3
Activity: 39
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