Dr. Karesh coined the term "One Health" in 2003 to describe the interdependence of healthy ecosystems, animals and people and has pioneered solutions-oriented initiatives with this concept as the guiding principle. International programs under his direction in over 45 countries have covered terrain from Argentina to Zambia and include efforts in the Congo Basin to reduce the impact of diseases such as Ebola, measles, and tuberculosis on humans and endangered species such as gorillas and chimpanzees, to global surveillance systems for emerging diseases.