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个人简介
The focus of Dr. Walley’s research is to investigate 1) the mechanism of decreased left ventricular contractility and other organ failure during sepsis and 2) the impact of genotype on patient outcomes in sepsis and systemic inflammatory states. Dr. Walley translates basic discoveries into clinical practice in the ICU. Together with Drs. Russell and Boyd, he recently demonstrated that blocking the function of PCSK9, an enzyme that inhibits the clearance of endogenous cholesterol from blood, is associated with increased pathogen clearance via the LDL-receptor, a decreased inflammatory response, and improved septic shock outcome. This important discovery facilitated the emergence of anti-PCSK9 therapies as one of the most promising treatments for sepsis. This discovery has led to further investigation into the role of lipoproteins in sepsis. T
raining the next generation of clinician scientists is the other passion in my career. I led a multicentre CIHR Strategic Training in Health Research project over the course of 12 years. This led to over 50 postdoctoral trainees launching prominent academic and industry careers.
raining the next generation of clinician scientists is the other passion in my career. I led a multicentre CIHR Strategic Training in Health Research project over the course of 12 years. This led to over 50 postdoctoral trainees launching prominent academic and industry careers.
研究兴趣
论文共 417 篇作者统计合作学者相似作者
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Haoyu Deng, Wan Yi Liang, Le Qi Chen, Tin Ho Yuen,Basak Sahin,Dragos M. Vasilescu,Mark Trinder,Keith Walley,Patrick C. N. Rensen,John H. Boyd,Liam R. Brunham
Yassene Mohammed,Karen Tran,Chris Carlsten,Christopher Ryerson,Alyson Wong,Terry Lee,Matthew P. Cheng,Donald C. Vinh,Todd C. Lee,Brent W. Winston,David Sweet,John H. Boyd,Keith R. Walley,Greg Haljan,Allison McGeer,Francois Lamontagne,Robert Fowler, David Maslove,Joel Singer,David M. Patrick,John C. Marshall,Srinivas Murthy, Fagun Jain,Christoph H. Borchers,David R. Goodlett,Adeera Levin,James A. Russell
Journal of Proteome Researchno. 1 (2024): 52-70
Diana N. Vikulova, Danielle Pinheiro-Muller,Gordon Francis, Frank Halperin,Tara Sedlak,Keith Walley,Christopher Fordyce, GB John Mancini,Simon N. Pimstone,Liam R. Brunham
American Journal of Preventive Cardiology (2024): 100704-100704
STEM CELLS TRANSLATIONAL MEDICINEno. 4 (2024): 346-361
Chel Hee Lee,Mohammad M. Banoei, Mariam Ansari,Matthew P. Cheng,Francois Lamontagne,Donald Griesdale, David E. Lasry,Koray Demir,Vinay Dhingra,Karen C. Tran,Terry Lee,Kevin Burns,David Sweet,John Marshall,Arthur Slutsky,Srinivas Murthy,Joel Singer,David M. Patrick,Todd C. Lee,John H. Boyd,Keith R. Walley,Robert Fowler,Greg Haljan,Donald C. Vinh,Alison Mcgeer,David Maslove,Puneet Mann,Kathryn Donohoe,Geraldine Hernandez,Genevieve Rocheleau,Uriel Trahtemberg,Anand Kumar, Ma Lou,Claudia dos Santos,Andrew Baker,James A. Russell,Brent W. Winston
Critical careno. 1 (2024)
Diana N. Vikulova, Danielle Pinheiro-Muller,Gordon Francis, Frank Halperin,Tara Sedlak,Keith Walley, Christopher Fordyce, GB John Mancini,Simon N. Pimstone,Liam R. Brunham
American Journal of Preventive Cardiology (2024): 100704
Terry Lee,Matthew P Cheng,Donald C Vinh,Todd C Lee,Karen C Tran,Brent W Winston,David Sweet,John H Boyd,Keith R Walley,Greg Haljan,Allison McGeer,Francois Lamontagne,Robert Fowler,David M Maslove,Joel Singer,David M Patrick,John C Marshall,Kevin D Burns,Srinivas Murthy,Puneet K Mann,Geraldine Hernandez,Kathryn Donohoe,James A Russell
CMAJ openno. 4 (2023): E672-E683
Patrick R Lawler,Garen Manvelian,Alida Coppi,Amy Damask,Michael N Cantor,Manuel A R Ferreira,Charles Paulding,Nilanjana Banerjee,Dadong Li, Susan Jorgensen,Richa Attre,David J Carey,Kristi Krebs,Lili Milani,Kristian Hveem,Jan K Damås,Erik Solligård,Stefan Stender,Anne Tybjærg-Hansen,Børge G Nordestgaard,Tamara Hernandez-Beeftink,Tormod Rogne,Carlos Flores,Jesús Villar,Keith R Walley,Vincent X Liu,Alison E Fohner,Luca A Lotta,Christos A Kyratsous,Mark W Sleeman,Michel Scemama,Richard DelGizzi,Robert Pordy,Julie E Horowitz,Aris Baras,Greg S Martin,Philippe Gabriel Steg, Gregory G Schwartz,Michael Szarek,Shaun G Goodman
Critical care explorationsno. 11 (2023): e0997-e0997
METABOLITESno. 11 (2023): 1142-1142
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2023)
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#Papers: 427
#Citation: 21096
H-Index: 72
G-Index: 135
Sociability: 8
Diversity: 0
Activity: 2
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