As an infectious disease specialist and clinical pharmacologist, Dr. Dooley maintains an active clinical practice in HIV care. Her research focuses on tuberculosis therapeutics with an emphasis on clinical trials of TB drugs and HIV/TB co-treatment, as well as clinical pharmacology of TB and HIV drugs. She is lead investigator for trials of therapeutics for drug-sensitive and drug-resistant TB, TB-HIV, and pediatric TB meningitis. She is on the TB scientific committees of the AIDS Clinical Trials Group and IMPAACT networks and is a consultant to World Health Organization on TB therapeutics and pharmacology.