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Research interests
The research interests of this investigator are within the frame of two major topics: (i) structural characterization of biological macromolecular assemblies, and (ii) nuclear proteins. The first includes both biochemical and biophysical approaches to the study of protein-protein and protein-DNA interactions. Chromatin is the particular biological system presently being analyzed in this area. Current research includes studies on histone-histone interactions, and on histone-DNA interactions at the nucleosome level and at the higher order structure of chromatin. Special attention is being paid to the influence on these interactions of biologically significant chemical modifications, both at the histone and at the DNA level (acetylation, phosphorylation, methylation).
The interest in the second topic comes from the fact that histones are not the only proteins that are associated with DNA inside the cell nucleus. These latter proteins may be, depending on the organism, displaced by a complex broad spectrum of other more basic proteins during the differentiation process of spermatogenesis. These spermatogenic proteins exhibit neither the compositional homogeneity nor the structural features of the typical histones. The current research in this area is centered on the chemistry of such proteins (characterization, sequencing) as well as on the molecular mechanisms involved in the regulation of the genes encoding these proteins.
The research interests of this investigator are within the frame of two major topics: (i) structural characterization of biological macromolecular assemblies, and (ii) nuclear proteins. The first includes both biochemical and biophysical approaches to the study of protein-protein and protein-DNA interactions. Chromatin is the particular biological system presently being analyzed in this area. Current research includes studies on histone-histone interactions, and on histone-DNA interactions at the nucleosome level and at the higher order structure of chromatin. Special attention is being paid to the influence on these interactions of biologically significant chemical modifications, both at the histone and at the DNA level (acetylation, phosphorylation, methylation).
The interest in the second topic comes from the fact that histones are not the only proteins that are associated with DNA inside the cell nucleus. These latter proteins may be, depending on the organism, displaced by a complex broad spectrum of other more basic proteins during the differentiation process of spermatogenesis. These spermatogenic proteins exhibit neither the compositional homogeneity nor the structural features of the typical histones. The current research in this area is centered on the chemistry of such proteins (characterization, sequencing) as well as on the molecular mechanisms involved in the regulation of the genes encoding these proteins.
研究兴趣
论文共 417 篇作者统计合作学者相似作者
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Nucleic acids research (2024)
Juan Ausio, Alistair Knox,Bo-Hyun Kim,Elaine Humphrey,Brent Gowen,Naoki Minamino,Patrick von Aderkas
Biochemistry and cell biology (2024)
Melissa R Leyden,Peter Michalik,Luciana Baruffaldi, Susheen Mahmood, Ladan Kalani,Donald F Hunt,Jose Maria Eirin-Lopez,Maydianne C B Andrade,Jeffrey Shabanowitz,Juan Ausió
bioRxiv : the preprint server for biology (2024)
Melissa R. Leyden,Brent Gowen,Rodrigo Gonzalez-Romero,Jose Maria Eirin-Lopez,Bo-Hyun Kim,Fumio Hayashi, Jay McCartney, Patrick C. Zhang,Miyoko Kubo-Irie,Jeffrey Shabanowitz,Donald F. Hunt,Patrick Ferree,Harold Kasinsky,Juan Ausió
Biochemistry and Cell Biologyno. 3 (2024): 238-251
Human molecular genetics online/Human molecular geneticsno. 1 (2023): 1-11
Tahir Muhammad, Stephen F. Pastore,Anna Mikhailov, Thulasi Madanagopal, Katrina Good,Juan Ausio,John B. Vincent
European Neuropsychopharmacology (2023)
EUROPEAN NEUROPSYCHOPHARMACOLOGY (2023): S248-S249
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作者统计
#Papers: 423
#Citation: 15931
H-Index: 59
G-Index: 108
Sociability: 7
Diversity: 4
Activity: 33
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