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Research Description
Dr. Rotter is a pioneer in the field of medical genetics, genetic epidemiology, and personalized medicine. He has engaged in the study of the genetic epidemiology of chronic common diseases for over 4 decades, with an emphasis on cardiovascular/metabolic diseases (coronary artery disease, dyslipidemia, hypertension, type 2 diabetes, insulin resistance, obesity, fatty liver, arrhythmias), gastrointestinal/autoimmune disorders (type 1 diabetes, inflammatory bowel disease, coeliac disease), ocular disorders (keratoconus, diabetic retinopathy, glaucoma), and pharmacogenetic studies. His studies have included family based, case control, cohort, and pharmacogenetic designs; have included different ethnic groups (Caucasian, Hispanics, African-Americans, Chinese, Ashkenazi Jews, and Armenians); and have ranged from linkage, candidate gene, genome-wide association (GWA) and post-GWA studies, and now whole exome and whole genome sequencing studies, and multi-omics studies (methylomics, transcriptomics, metabolomics). The ultimate goal of this work is to identify the optimal therapy and prevention for cardiometabolic and ocular disorders as a function of an individual’s genetic predisposition. Thus, this is the basis for precision/personalized medicine, especially in minority populations.
研究兴趣
论文共 1685 篇作者统计合作学者相似作者
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Bahar Sedaghati-khayat,Jingyi Tan,Jie Yao, Tapati Mazumdar, Maxime Bos, Katherine Cerniglia, Linda Broer,Kent D. Taylor,Xiaohui Li, Joyce Van Meurs, Arfan Ikram, Shubhi Bartaria,
EUROPEAN JOURNAL OF HUMAN GENETICS (2024): 703-704
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Nature Communicationsno. 1 (2024): 1-17
Circulation. Genomic and precision medicinepp.e004272-e004272, (2024)
Natalie Marrero,Kunal Jha,Timothy M. Hughes, Alexander C. Razavi,Jelani K. Grant,Ellen Boakye,Khalil Anchouche,Omar Dzaye,Matthew J. Budoff,Jerome I. Rotter,Xiuqing Guo,Jie Yao,
Atherosclerosisno. 13 (2024): 117596
Marios K Georgakis,Rainer Malik, Omar El Bounkari,Natalie R Hasbani, Jiang Li, Jennifer E Huffman,Gabrielle Shakt, Reinier W P Tack, Tamara N Kimball, Yaw Asare,Alanna C Morrison,Noah L Tsao,
medRxiv : the preprint server for health sciences (2024)
CELLno. 2 (2024): 464-480.e10
Shuke Xiao,Veronica L. Li,Xuchao Lyu, Xudong Chen,Wei Wei,Fahim Abbasi,Joshua W. Knowles, Alan Sheng-Hwa Tung,Shuliang Deng, Gaurav Tiwari,Xu Shi,Shuning Zheng,
Nature Metabolismpp.1-11, (2024)
Matthew O Goodman,Tariq Faquih,Valentina Paz, Pavithra Nagarajan,Jacqueline M Lane, Brian Spitzer,Matthew Maher,Joon Chung,Brian E Cade,Shaun M Purcell,Xiaofeng Zhu,Raymond Noordam,
medRxiv : the preprint server for health sciences (2024)
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