My primary research interest is understanding the role of genomic variation with traits relevant to cardiovascular health and aging.

Locally, I have pursued these questions within the Cardiovascular Health Study and the Heart and Vascular Health Studies. I am also involved in several large-scale genomics collaborations: as a co-lead or working groups in the CHARGE consortium and the Alzheimer’s Disease Sequencing Project as well as as through the NHLBI’s Exome Sequencing Project (ESP), the Trans-Omics for Precision Medicine (TOPMed) Program, and in the International Genomics of Alzheimer’s Project (IGAP).

In these settings, my work has focused on analysis methods, drug-gene interactions, clinical and subclinical atherosclerosis, cardiovascular risk factors, and a broad range of neurological traits including stroke, brain imaging endophenotypes, and Alzheimer’s disease.