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Research Interests
Elucidating the mechanistic basis of T cell dysfunction in human cancer; designing and testing the next generation of genetically-directed CAR T cells as immunotherapy for patients with cancer; epigenetic programming of immune cells; dissecting the signaling/molecular requirements for generation of effective memory and effector T cell responses
Research Summary
Research in the Fraietta laboratory focuses on the generation of innovative immunotherapy strategies involving T cells and their impact on immunity, tumor biology and the tissue/tumor microenvironment in the setting of translatable preclinical studies. We use primary patient samples, in vitro systems and cutting-edge animal models to 1) understand the factors and mechanisms associated with successful adoptive transfer of T cells, with the goal of improving the functions of both endogenous and gene-modified T cells, 2) develop mechanism-based strategies to enhance the survival, expansion and potency of infused T cell products directed against tumors and viral pathogens, and 3) devise methods to modulate the host immune environment to optimally activate T cells.
Elucidating the mechanistic basis of T cell dysfunction in human cancer; designing and testing the next generation of genetically-directed CAR T cells as immunotherapy for patients with cancer; epigenetic programming of immune cells; dissecting the signaling/molecular requirements for generation of effective memory and effector T cell responses
Research Summary
Research in the Fraietta laboratory focuses on the generation of innovative immunotherapy strategies involving T cells and their impact on immunity, tumor biology and the tissue/tumor microenvironment in the setting of translatable preclinical studies. We use primary patient samples, in vitro systems and cutting-edge animal models to 1) understand the factors and mechanisms associated with successful adoptive transfer of T cells, with the goal of improving the functions of both endogenous and gene-modified T cells, 2) develop mechanism-based strategies to enhance the survival, expansion and potency of infused T cell products directed against tumors and viral pathogens, and 3) devise methods to modulate the host immune environment to optimally activate T cells.
研究兴趣
论文共 185 篇作者统计合作学者相似作者
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Alexander E. Doan,Katherine P. Mueller,Andy Y. Chen,Geoffrey T. Rouin,Yingshi Chen,Bence Daniel,John Lattin,Martina Markovska,Brett Mozarsky,Jose Arias-Umana,Robert Hapke,In-Young Jung,Alice Wang,Peng Xu,Dorota Klysz, Gabrielle Zuern,Malek Bashti,Patrick J. Quinn,Zhuang Miao,Katalin Sandor,Wenxi Zhang,Gregory M. Chen, Faith Ryu,Meghan Logun,Junior Hall,Kai Tan,Stephan A. Grupp,Susan E. Mcclory,Caleb A. Lareau,Joseph A. Fraietta,Elena Sotillo,Ansuman T. Satpathy,Crystal L. Mackall,Evan W. Weber
NATUREno. 8011 (2024): E11-E11
Julie K. Jadlowsky,Rachel Leskowitz, Stephen Mckenna,Jayashree Karar,Yujie Ma, Anlan Dai,Gabriela Plesa,Fang Chen, Kathleen Alexander, Jennifer Petrella, Nan Gong,Wei -Ting Hwang,Olivia Farrelly,Julie Barber-Rotenberg,Shannon Christensen,Vanessa E. Gonzalez,Anne Chew,Joseph A. Fraietta,Carl H. June
Molecular therapy Methods & clinical developmentno. 1 (2024): 101186-101186
Alexander Doan,Katherine Mueller,Andy Chen,Geoffrey Rouin,Yingshi Chen,Bence Daniel,John Lattin,Martina Markovska,Brett Mozarsky,Jose Arias-Umana,Robert Hapke,In-Young Jung,Alice Wang,Peng Xu,Dorota Klysz, Gabrielle Zuern,Malek Bashti,Patrick Quinn,Zhuang Miao,Katalin Sandor,Wenxi Zhang,Gregory Chen, Faith Ryu,Meghan Logun,Junior Hall,Kai Tan,Stephan Grupp,Susan Mcclory,Caleb Lareau,Joseph Fraietta,Elena Sotillo,Ansuman Satpathy,Crystal Mackall,Evan Weber
Ju-Fang Chang, Nils Wellhausen, Nils W. Engel,Jack H. Landmann,Caitlin R. Hopkins, January Salas-McKee,Adham S. Bear, Mehmet E. Selli,Sangya Agarwal,Julie K. Jadlowsky, Gerald P. Linette,Saar Gill,Carl H. June,Joseph A. Fraietta, Nathan Singh
crossref(2024)
Stephen J. Bagley,Meghan Logun,Joseph A. Fraietta,Xin Wang,Arati S. Desai,Linda J. Bagley,Ali Nabavizadeh,Danuta Jarocha,Rene Martins,Eileen Maloney,Lester Lledo, Carly Stein,Amy Marshall,Rachel Leskowitz,Julie K. Jadlowsky,Shannon Christensen, Bike Su Oner,Gabriela Plesa,Andrea Brennan,Vanessa Gonzalez,Fang Chen,Yusha Sun,Whitney Gladney,David Barrett,MacLean P. Nasrallah,Wei-Ting Hwang,Guo-Li Ming,Hongjun Song,Donald L. Siegel,Carl H. June,Elizabeth O. Hexner,Zev A. Binder,Donald M. O’Rourke
bioRxiv : the preprint server for biology (2024)
CANCER IMMUNOLOGY RESEARCHno. 9 (2024): 1136-1146
Guido Ghilardi,Joseph A. Fraietta,James N. Gerson,Vivianna M. Van Deerlin,Jennifer J. D. Morrissette,Gabriel C. Caponetti,Luca Paruzzo,Jaryse C. Harris,Elise A. Chong,Sandra P. Susanibar Adaniya,Jakub Svoboda,Sunita D. Nasta,Ositadimma H. Ugwuanyi,Daniel J. Landsburg,Eugenio Fardella,Adam J. Waxman,Emeline R. Chong, Vrutti Patel,Raymone Pajarillo,Irina Kulikovskaya,David B. Lieberman,Adam D. Cohen,Bruce L. Levine,Edward A. Stadtmauer,Noelle V. Frey,Dan T. Vogl,Elizabeth O. Hexner,Stefan K. Barta,David L. Porter,Alfred L. Garfall,Stephen J. Schuster,Carl H. June,Marco Ruella
Nature Medicinepp.1-6, (2024)
Guido Ghilardi,Luca Paruzzo,Jakub Svoboda,Elise A. Chong,Alexander A. Shestov,Linhui Chen,Ivan J. Cohen,Giulia Gabrielli,Sunita D. Nasta,Patrizia Porazzi,Daniel J. Landsburg,James N. Gerson,Jordan Carter,Stefan K. Barta,Rebecca Yelton,Raymone Pajarillo, Vrutti Patel,Griffin White,Hatcher J. Ballard,Elizabeth Weber,Ellen Napier,Emeline R. Chong,Joseph A. Fraietta,Alfred L. Garfall,David L. Porter,Michael C. Milone,Roderick O'Connor,Stephen J. Schuster,Marco Ruella
Blood Advancesno. 3 (2024): 653-666
Regina M. Myers,Kaitlin Devine,Yimei Li, Sophie Lawrence,Allison Barz Leahy,Hongyan Liu,Lauren Vernau,Colleen Callahan,Diane Baniewicz,Stephan Kadauke,Regina McGuire,Gerald B. Wertheim,Irina Kulikovskaya,Vanessa E. Gonzalez,Joseph A. Fraietta,Amanda M. DiNofia,Stephen P. Hunger,Susan R. Rheingold,Richard Aplenc,Carl H. June,Stephan A. Grupp,Lisa Wray,Shannon L. Maude
BLOOD ADVANCESno. 9 (2024): 2182-2192
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作者统计
#Papers: 184
#Citation: 8981
H-Index: 32
G-Index: 94
Sociability: 7
Diversity: 0
Activity: 3
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