Joseph F. Arboleda-Velasquez
Associate Professor
Age-related Macular Degeneration Center of Excellence
Department of Ophthalmology, Harvard Medical School, Harvard University;Diabetic Eye Disease Center of Excellence, Department of Ophthalmology, Harvard Medical School, Harvard University;Schepens Eye Research Institute, Harvard University;Massachusetts Eye and Ear, Harvard University
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基本信息
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Career Trajectory
Bio
Dr. Arboleda-Velasquez’s research is focused on the genetics and pathobiology of neurodegenerative diseases of the brain and the retina.
Dr. Arboleda-Velasquez’s early career work on CADASIL, an inherited form of stroke and vascular dementia, took him from the clinical characterization of two families in his home country of Colombia to Harvard Medical School, where he conducted molecular studies of mutant Notch 3 receptors in culture systems. He also generated novel knock-in mouse models that replicated a genotype-phenotype correlation first observed in his CADASIL patients, and leveraged inducible cell ablation studies in mice to provide evidence that pericytes help regulate microvascular stability in adult neural tissues. Dr. Arboleda-Velasquez recently took his CADASIL work towards translational applications by characterizing blood biomarkers linked to the pathobiology of the disease and by establishing the preclinical feasibility of a treatment modality based on Notch 3 signaling normalization using therapeutic antibodies.
Dr. Arboleda-Velasquez’s early career work on CADASIL, an inherited form of stroke and vascular dementia, took him from the clinical characterization of two families in his home country of Colombia to Harvard Medical School, where he conducted molecular studies of mutant Notch 3 receptors in culture systems. He also generated novel knock-in mouse models that replicated a genotype-phenotype correlation first observed in his CADASIL patients, and leveraged inducible cell ablation studies in mice to provide evidence that pericytes help regulate microvascular stability in adult neural tissues. Dr. Arboleda-Velasquez recently took his CADASIL work towards translational applications by characterizing blood biomarkers linked to the pathobiology of the disease and by establishing the preclinical feasibility of a treatment modality based on Notch 3 signaling normalization using therapeutic antibodies.
Research Interests
Papers共 104 篇Author StatisticsCo-AuthorSimilar Experts
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Claudia Marino,Paula Perez-Corredor,Michael O'Hare, Annie Heuer,Natalia Chmielewska,Harper Gordon,Anita S. Chandrahas,Lucia Gonzalez-Buendia,Santiago Delgado-Tirado, Tri H. Doan, Timothy E. Vanderleest,Said Arevalo-Alquichire, Robert A. Obar, Carolina Ortiz-Cordero,Andres Villegas,Diego Sepulveda-Falla,Leo A. Kim,Francisco Lopera,Robert Mahley,Yadong Huang,Yakeel T. Quiroz,Joseph F. Arboleda-Velasquez
ALZHEIMERS & DEMENTIAno. 2 (2024): 819-836
Jonah N. Keller,Hannah Radabaugh,Nikolaos Karvelas,Stephen Fitzsimons, Scott Treiman, Maria F. Palafox, Lisa McDonnell,Yakeel T. Quiroz,Francisco J. Lopera, Debarag Banerjee,Michael M. Wang,Joseph F. Arboleda-Velasquez,James F. Meschia,Adam R. Ferguson,Fanny M. Elahi
crossref(2024)
Yakeel T Quiroz,David Aguillon,Daniel C Aguirre-Acevedo,Daniel Vasquez,Yesica Zuluaga,Ana Y Baena,Lucia Madrigal,Liliana Hincapié,Justin S Sanchez,Stephanie Langella,Rafael Posada-Duque, Jessica L Littau, Nelson D Villalba-Moreno,Clara Vila-Castelar,Liliana Ramirez Gomez,Gloria Garcia, Elizabeth Kaplan, Sofia Rassi Vargas, J Alejandro Ossa,Pablo Valderrama-Carmona,Paula Perez-Corredor,Susanne Krasemann,Markus Glatzel,Kenneth S Kosik,Keith Johnson,Reisa A Sperling,Eric M Reiman,Diego Sepulveda-Falla,Francisco Lopera,Joseph F Arboleda-Velasquez
The New England journal of medicineno. 23 (2024): 2156-2164
Paula Perez-Corredor, Timothy E. Vanderleest,Guido N. Vacano,Justin S. Sanchez, Nelson D. Villalba-Moreno,Claudia Marino,Susanne Krasemann,Miguel A. Mendivil-Perez,David Aguillon,Marlene Jimenez-Del-Rio,Ana Baena,Diego Sepulveda-Falla,Francisco Lopera,Yakeel T. Quiroz,Joseph F. Arboleda-Velasquez,Randall C. Mazzarino
Frontiers in Molecular Neuroscience (2024): 1373568-1373568
Francisco Lopera,Claudia Marino,Anita S. Chandrahas,Michael O’Hare,Nelson David Villalba-Moreno,David Aguillon,Ana Baena,Justin S. Sanchez,Clara Vila-Castelar,Liliana Ramirez Gomez,Natalia Chmielewska,Gabriel M. Oliveira,Jessica Lisa Littau,Kristin Hartmann, Kyungeun Park,Susanne Krasemann,Markus Glatzel,Dorothee Schoemaker,Lucia Gonzalez-Buendia,Santiago Delgado-Tirado,Said Arevalo-Alquichire,Kahira L. Saez-Torres,Dhanesh Amarnani,Leo A. Kim,Randall C. Mazzarino,Harper Gordon,Yamile Bocanegra,Andres Villegas,Xiaowu Gai,Moiz Bootwalla,Jianling Ji,Lishuang Shen,Kenneth S. Kosik,Yi Su,Yinghua Chen,Aaron Schultz,Reisa A. Sperling,Keith Johnson,Eric M. Reiman,Diego Sepulveda-Falla,Joseph F. Arboleda-Velasquez,Yakeel T. Quiroz
Nature medicineno. 5 (2023): 1243-1252
Yakeel T. Quiroz,David Aguillón, Yesica Zuluaga‐Castaño,Ana Baena,Daniel Vásquez,Gloria García,Lucía Madrigal, Liliana Hincapié,Justin S. Sanchez, Diego Sepúlveda‐Falla,Clara Vila‐Castelar, Liliana Ramírez Gómez, Paula Aduen,Juliana Acosta‐Uribe,Kenneth S. Kosik,Keith A. Johnson,Reisa A. Sperling,Eric M. Reiman,Francisco Lopera,Joseph F. Arboleda‐Velásquez
Alzheimer's & dementiano. S12 (2023)
Nicholas Barksdale,Stephanie Langella,Daniel Vasquez,David Aguillon,Yinghua Chen,Yi Su, Natalia Acosta Baena, Juliana Acosta Uribe,Ana Baena,Gloria Garcia-Ospina,Margarita Giraldo-Chica,Victoria Tirado,Claudia Munoz,Claudia Guzman,Silvia Rios-Romenets,Gabriel Oliveira,Hyun-Sik Yang,Clara Vila-Castelar,Jeremy Pruzin,Valentina Ghisays,Joseph Arboleda-Velasquez,Kenneth Kosik,Eric Reiman,Francisco Lopera,Yakeel T. Quiroz
NEUROLOGYno. 17 (2023)
Maxine R. Nelson, Peng Liu,Ayushi Agrawal,Oscar Yip,Jessica Blumenfeld,Michela Traglia,Min Joo Kim,Nicole Koutsodendris,Antara Rao,Brian Grone,Yanxia Hao,Seo Yeon Yoon,Qin Xu, Samuel De Leon, Tenzing Choenyi,Reuben Thomas,Francisco Lopera,Yakeel T. Quiroz,Joseph F. Arboleda-Velasquez,Eric M. Reiman,Robert W. Mahley,Yadong Huang
Nature Neuroscienceno. 12 (2023): 2104-2121
Stephanie Langella, N. Gil Barksdale,Daniel Vasquez,David Aguillon,Yinghua Chen,Yi Su,Natalia Acosta-Baena,Juliana Acosta-Uribe,Ana Y. Baena,Gloria Garcia-Ospina,Margarita Giraldo-Chica,Victoria Tirado,Claudia Muñoz,Silvia Ríos-Romenets, Claudia Guzman-Martínez,Gabriel Oliveira,Hyun-Sik Yang,Clara Vila-Castelar,Jeremy J. Pruzin,Valentina Ghisays,Joseph F. Arboleda-Velasquez,Kenneth S. Kosik,Eric M. Reiman,Francisco Lopera,Yakeel T. Quiroz
Nature communicationsno. 1 (2023)
William Phillip Miller,Said Arevalo-Alquichire, Audrey Gunawan,Elizabeth Rossin,Michael O'Hare,Joseph Arboleda-Velasquez,Leo A. Kim
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCEno. 8 (2023)
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#Papers: 104
#Citation: 2503
H-Index: 23
G-Index: 49
Sociability: 6
Diversity: 0
Activity: 1
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