His main research involves studying the causes and prevention of cardiovascular diseases through the design, conduct and analysis of large-scale observational cohort studies, randomised controlled trials, and individual-participant-data meta-analyses of both types of study.
Jonathan is the UK Principal Investigator and MRC Population Health Research Unit (MRC-PHRU) Programme Leader for the Mexico City Prospective Study, a blood-based prospective cohort study of 150,000 Mexican adults followed for more than 15 years.