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Cancer is an evolutionary process that typically spans multiple decades before it causes symptoms. The survival probability of patients with a tumor diagnosed early is five to ten times higher than when diagnosed at an advanced stage. The last stage of cancer progression, metastasis, is responsible for 90% of cancer-related deaths. In a tumor with billions of cells virtually any point mutation is expected to be present in a few cells. Hence, at a genetic level, not only is every cancer type different, but also every tumor of the same type and every cell of the same tumor are different. This enormous heterogeneity poses a major barrier to drug development and long-term disease control but also represents a unique opportunity to study the evolutionary principles that govern cancer initiation and progression.
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论文共 47 篇作者统计合作学者相似作者
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Preethi Srinivasan, Tzu-Chun Chen, Ehsan Haghshenas, Misagh Kordi, Ilker Tunc, Wenching Chan, Omid Shams Solari, Joshua Babiarz,Yoshiaki Nakamura, Takayuki Yoshino,Alexey Aleshin, Trupti Kawli,
Cancer Researchno. 6_Supplement (2024): 2409-2409
Parvathi A. Myer, Preethi Srinivasan, Sara L. Bristow,Shifra Krinshpun, Omid Shams Solari,Vasily N. Aushev,Adham Jurdi,Minetta C. Liu, Breeana L. Mitchell,Alexey Aleshin,Johannes G. Reiter, Jeffrey N. Weitzel,
Gastroenterologyno. 5 (2024): S-373
Preethi Srinivasan, Boris Gutman, Sara L. Bristow, Hsin-Ta Wu,Raheleh Salari,Ryan Swenerton, Trupti Kawli,Alexey Aleshin,Matthew Rabinowitz,Bernhard Zimmermann, Breeana L. Mitchell,Johannes G. Reiter
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTIONno. 12 (2023): S183-S184
Preethi Srinivasan, Boris Gutman,Vasily Aushev,Shruti Sharma, Taly Arbel,Hsin-Ta Wu,Meenakshi Malhotra,Raheleh Salari,Bernhard Zimmermann,Ryan Swenerton, Trupti Kawli, Breeana Mitchell,
CANCER PREVENTION RESEARCHno. 1 (2023)
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Preethi Srinivasan, Boris A. Gutman,Vasily N. Aushev, Swati Sharma, Taly Arbel,Hsin-Ta Wu,Meenakshi Malhotra,Raheleh Salari,Bernhard Zimmermann,Ryan Swenerton, Trupti Kawli, Breeana L. Mitchell,
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