基本信息
views: 80
Career Trajectory
Bio
The long-term central goal of my career is to improve the outcomes of drug treatment by conducting first class biomedical research. To accomplish this goal I am building a research program that aims to improve drug treatment by discovery of novel pharmacogenetic biomarkers and subsequent translation to clinical practice, thereby providing a cornerstone for precision medicine. This work is seamlessly integrated with my work as chair of the pharmacy laboratory. I’m one of the primary investigators of the “Ubiquitous Pharmacogenomics” project (www.upgx.eu). I have published multiple papers on the identification of barriers for clinical implementation of pharmacogenomics and the development of approaches to overcome them. In addition I (co)authored pharmacogenomic guidelines and am an active member of the Dutch Pharmacogenetics Working Group and the Clinical Pharmacogenetics Implementation Consortium.
Recently I have initiated a novel fundamental research line focusing on elucidating the frequently observed mismatch between the genotype and the capacity of an individual to metabolize drugs (phenotype). This phenomenon is called phenoconversion and presents a significant problem for the clinical implementation of pharmacogenetics. Underlying mechanisms involve both drug-drug interactions as well as disease state.
Recently I have initiated a novel fundamental research line focusing on elucidating the frequently observed mismatch between the genotype and the capacity of an individual to metabolize drugs (phenotype). This phenomenon is called phenoconversion and presents a significant problem for the clinical implementation of pharmacogenetics. Underlying mechanisms involve both drug-drug interactions as well as disease state.
Research Interests
Papers共 248 篇Author StatisticsCo-AuthorSimilar Experts
By YearBy Citation主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Clinical Pharmacology & Therapeuticsno. 1 (2024): 155-164
Clinical and translational scienceno. 2 (2024): e13729-e13729
Journal of the American College of Cardiologyno. 12 (2024): 1107-1118
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2024)
Laura M de Jong, Chandan Harpal,Dirk-Jan van den Berg,Menno Hoekstra, Nienke J Peter,Robert Rissmann,Jesse J Swen,Martijn L Manson
Drug metabolism and disposition the biological fate of chemicalsno. 12 (2024): 1429-1437
Journal of the American College of Cardiologyno. 12 (2024): 1107-1118
N. Heersche,J.E. Knikman,M. De With,M. Lopez-Yurda,A. Baars,G-J. Creemers, H. Droogendijk,E. Fiets,M. Deenen, R. Van Schaik, B. van den Bosch, E. Oomen-de Hoop, H. Rosing,J. Swen, H. Gelderblom, J.H.M. Schellens, J.H. Beijnen,R.H. Mathijssen,H-J. Guchelaar, A. Cats
Annals of Oncology (2024)
CLINICAL PHARMACOLOGY & THERAPEUTICSno. 6 (2024): 1282-1292
EUROPEAN JOURNAL OF HUMAN GENETICSno. 2 (2024): 155-162
Load More
Author Statistics
#Papers: 248
#Citation: 8061
H-Index: 41
G-Index: 86
Sociability: 7
Diversity: 3
Activity: 75
Co-Author
Co-Institution
D-Core
- 合作者
- 学生
- 导师
Data Disclaimer
The page data are from open Internet sources, cooperative publishers and automatic analysis results through AI technology. We do not make any commitments and guarantees for the validity, accuracy, correctness, reliability, completeness and timeliness of the page data. If you have any questions, please contact us by email: report@aminer.cn