基本信息
浏览量:2
职业迁徙
个人简介
I am currently Professor of Molecular Microbiology, working within the Microbiology Research Grouping in the Faculty. I obtained my first degree, and then PhD, from the University of Cambridge, before moving on to work in Prof Bill Shaw's group in Leicester. This gave me a background in the use of structural analysis in the study of protein function, as applied to the enzyme chloramphenicol acetyltransferase (CAT). I then obtained a Postdoctoral Research Fellowship from the Wellcome Trust, to work on the antibody-binding protein, Protein G, from Streptococcus, which is widely used in affinity resins for purifying antibodies. Working with Gordon Roberts and Lu-Yun Lian in the Biological NMR Centre in Leicester, we published the first description of the structure of this important protein. Working with Dale Wigley, we also determined the crystal structure of a Protein G domain bound to an Fab fragment, revealing the molecular basis for its recognition of antibody (Nature 359, 752-754). This started my interest in bacterial cell surface proteins- the structures they adopt, how they function and interact with the immune system. In 1993, I moved to UMIST as a lecturer, and have been at Manchester ever since. At this time, I started to work on the outer membrane proteins (OMPs) from Neisseria meningitidis, the causative agent of meningococcal meningitis. This work was initially funded through a Lister Fellowship, which I held between 1996 and 2001. Working with Mark Achtman's lab in Berlin, we were the first group to publish a crystal structure of an outer membrane protein from Neisseria, the OpcA protein (PNAS 99, 3417-3421). In parallel, I also investigated the interaction of the immune system with Neisserial OMPs, through collaborations with Martin Maiden (Oxford) and Ian Feavers (NIBSC). OMPs such as the PorA porin have been shown to provide protective immunity against meningococcal meningitis, and have been used as constituents of vaccines against the disease. This work has recently translated into Wellcome Trust Translation Award with Andrew Pollard (Oxford), Martin Maiden and Ian Feavers, aiming to develop a new approach to immunization against meningococcal disease. My lab has also focused on the biogenesis of type IV pili in Gram negative bacteria. Type IV pili play major roles in bacterial cell adhesion, DNA transformation and motility. They are assembled through the action of a complex group of proteins which span the inner and outer membranes, acting effectively as a macromolecular machine. In a collaboration with Tone Tonjum in Oslo and Bob Ford's group in Manchester, we have worked on the characterisation of the PilQ outer membrane secretin by electron microscopy (J Biol Chem 279, 39750-39756), revealing an unusual chamber-like structure which mediates the passage of type IV pili across the outer membrane. More recent work has concentrated on the determination of the structures of the component proteins within the assembly machine (eg J Mol Biol 364, 186-195) and earlier this year we published the first crystal structure of a complex between two type IV pilus assembly proteins (J Biol Chem 286, 24434-42).
I have always maintained a strong interest in commercial and industrial applications of my work. I was a co-founder, with Prof Bill Shaw and Drs Bill Primrose and Ann Lewendon, of a biotechnology/ pharmaceutical start-up company called PanTherix in 1997. More recently, I obtained a grant from BBSRC under the Bioprocessing Research Industry Club (BRIC) initiative, working with Jim Warwicker in my Faculty and Robin Curtis in Chemical Engineering. Our aim is to investigate better methods for understanding and predicting protein aggregation, which is a significant problem in the bioprocess industry.
I have always maintained a strong interest in commercial and industrial applications of my work. I was a co-founder, with Prof Bill Shaw and Drs Bill Primrose and Ann Lewendon, of a biotechnology/ pharmaceutical start-up company called PanTherix in 1997. More recently, I obtained a grant from BBSRC under the Bioprocessing Research Industry Club (BRIC) initiative, working with Jim Warwicker in my Faculty and Robin Curtis in Chemical Engineering. Our aim is to investigate better methods for understanding and predicting protein aggregation, which is a significant problem in the bioprocess industry.
研究兴趣
论文共 157 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
The journal of antimicrobial chemotherapy/Journal of antimicrobial chemotherapy (2024)
Lenka Stejskal,Angela Thistlethwaite, Fidel Ramirez-Bencomo, Smruti Rashmi,Odile Harrison,Ian M. Feavers,Martin C. J. Maiden, Ann Jerse, Grace Barnes, Oscar Chirro, James Chemweno, Eunice Nduati, Ana Cehovin,Christoph Tang,Eduard J. Sanders,Jeremy P. Derrick
NATURE COMMUNICATIONSno. 1 (2024)
Alina Kulakova,Dillen Augustijn,Inas El Bialy,Lorenzo Gentiluomo,Maria Laura Greco,Stefan Hervo-Hansen,Sowmya Indrakumar,Sujata Mahapatra,Marcello Martinez Morales,Christin Pohl,Marco Polimeni,Aisling Roche,Hristo L. Svilenov,Andreas Tosstorff,Matja Zalar,Robin Curtis,Jeremy P. Derrick,Wolfgang Friess,Alexander P. Golovanov,Mikael Lund,Allan Norgaard,Tarik A. Khan,Gunther H. J. Peters,Alain Pluen,Dierk Roessner,Werner W. Streicher,Christopher F. van der Walle,Jim Warwicker,Shahid Uddin,Gerhard Winter,Jens Thostrup Bukrinski,Asmund Rinnan,Pernille Harris
NPJ vaccinesno. 1 (2023): 54-15
Molecular Pharmaceuticsno. 7 (2023): 3559-3569
The Journal of infectionno. 6 (2023): 479-489
Vaccineno. 28 (2022): 3835-3842
加载更多
作者统计
#Papers: 160
#Citation: 5024
H-Index: 38
G-Index: 66
Sociability: 6
Diversity: 0
Activity: 1
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn