Jennifer E Huffman - MRC Institute of Genetics and Molecular Medicine, University of Edinburgh

基本信息

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Bio

I am interested in the analysis of large genetic datasets as they relate to human health and disease. My main focus is how genetic data (SNPs, WES, WGS, methylation, RNA expression) influence normal variation in levels of hemostatic factors and platelet-related traits and how they may contribute to disease risk. My secondary research focus is to apply the same techniques to investigate renal function, uric acid and gout. I contribute to several large consortia including CHARGE, CKDGen & TOPMed.

Research Interests

Papers共 230 篇Author StatisticsCo-AuthorSimilar Experts

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Comparison of Methods for Building Polygenic Scores for Diverse Populations

Sophia Gunn, Xin Wang,Daniel C. Posner,Kelly Cho,Jennifer E. Huffman,Michael Gaziano,Peter W. Wilson,Yan V. Sun,Gina Peloso,Kathryn L. Lunetta

HUMAN GENETICS AND GENOMICS ADVANCESno. 1 (2025)

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Accelerating Genome- and Phenome-Wide Association Studies Using GPUs – A Case Study Using Data from the Million Veteran Program

bioRxiv the preprint server for biology (2024)

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Rare Damaging CCR2 Variants Are Associated with Lower Lifetime Cardiovascular Risk

Marios K Georgakis,Rainer Malik,Omar El Bounkari,Natalie R Hasbani,Jiang Li,Jennifer E Huffman,Gabrielle Shakt, Reinier W P Tack,Tamara N Kimball,Yaw Asare,Alanna C Morrison,Noah L Tsao,Renae Judy,Braxton D Mitchell,Huichun Xu,May E Montasser,Ron Do,Eimear E Kenny,Ruth J F Loos,James G Terry,John Jeffrey Carr,Joshua C Bis,Bruce M Psaty,W T Longstreth,Kendra A Young,Sharon M Lutz,Michael H Cho,Jai Broome,Alyna T Khan, Fei,Nancy Heard-Costa,Sudha Seshadri,Ramachandran S Vasan,Nicholette D Palmer,Barry I Freedman,Donald W Bowden,Lisa R Yanek,Brian G Kral,Lewis C Becker,Patricia A Peyser,Lawrence F Bielak,Farah Ammous,April P Carson,Michael E Hall,Laura M Raffield,Stephen S Rich,Wendy S Post,Russel P Tracy,Kent D Taylor,Xiuqing Guo,Michael C Mahaney,Joanne E Curran,John Blangero,Shoa L Clarke,Jeffrey W Haessler,Yao Hu,Themistocles L Assimes,Charles Kooperberg,Jürgen Bernhagen,Christopher D Anderson,Scott M Damrauer,Ramin Zand,Jerome I Rotter,Paul S de Vries,Martin Dichgans

medRxiv the preprint server for health sciences（2024）

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Genome-wide Association Study Reveals Mechanisms Underlying Dilated Cardiomyopathy and Myocardial Resilience

Sean J Jurgens,Joel T Rämö, Daria R Kramarenko, Leonoor F J M Wijdeveld,Jan Haas,Mark D Chaffin, Sophie Garnier,Liam Gaziano,Lu-Chen Weng, Alex Lipov,Sean L Zheng,Albert Henry,Jennifer E Huffman, Saketh Challa,Frank Rühle, Carmen Diaz Verdugo,Christian Krijger Juárez,Shinwan Kany, Constance A van Orsouw,Kiran Biddinger,Edwin Poel, Amanda L Elliott, Xin Wang,Catherine Francis, Richard Ruan,Satoshi Koyama,Leander Beekman,Dominic S Zimmerman,Jean-François Deleuze,Eric Villard, David-Alexandre Trégouët, Richard Isnard, FinnGen,VA Million Veteran Program, HERMES Consortium,Dorret I Boomsma,Eco J C de Geus,Rafik Tadros,Yigal M Pinto,Arthur A M Wilde,Jouke-Jan Hottenga,Juha Sinisalo,Teemu Niiranen,Roddy Walsh,Amand F Schmidt,Seung Hoan Choi,Kyong-Mi Chang,Philip S Tsao,Paul M Matthews,James S Ware,R Thomas Lumbers, Saskia van der Crabben,Jari Laukkanen,Aarno Palotie,Ahmad S Amin, Philippe Charron,Benjamin Meder,Patrick T Ellinor,Mark Daly,Krishna G Aragam,Connie R Bezzina

Nature geneticsno. 12 (2024): 2636-2645

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Abstract 4138407: Exome-wide Association Study of over a Million Individuals Identified Effector Genes and Variants for Blood Lipids

Satoshi Koyama, Zhi Yu,Seung Hoan Choi, Sean Jurgens,Margaret Selvaraj,Derek Klarin,Jennifer Huffman, Michael Trinh, Akshaya Ravi,Jacqueline Dron, Catherine Spinks,Ida Surakka,Whitney Hornsby,Scott Damrauer,Kyong-Mi Chang,Themistocles Assimes,Philip Tsao,Daniel Rader, Kelly Kim,Gina Peloso,Patrick Ellinor, Yan Sun,Peter Wilson,Pradeep Natarajan

Circulationno. Suppl_1 (2024)

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Factors That Modulate Platelet Reactivity As Measured by 5 Assay Platforms in 3429 Individuals

Melissa V. Chan,Ming-Huei Chen,Florian Thibord,Bongani B. Nkambule,Amber R. Lachapelle,Joseph Grech,Zoe E. Schneider, Catherine Wallace de Melendez,Jennifer E. Huffman,Melissa A. Hayman,Harriet E. Allan,Paul C. Armstrong,Timothy D. Warner,Andrew D. Johnson

RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASISno. 3 (2024)

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Polygenic Scores for Obstructive Sleep Apnea Based on BMI- Adjusted and - Unadjusted Genetic Associations Reveal Pathways Contributing to Cardiovascular Disease

Nuzulul Kurniansyah,Satu Strausz,Geetha Chittoor, Shreyash Gupta,Anne E Justice, Yana Hrytsenko,Brendan T Keenan,Brian E Cade,Brian W Spitzer,Heming Wang,Jennifer E Huffman,Matthew Moll,Bernhard Haring,Su Yon Jung,Laura M. Raffield,Robert C. Kaplan,Jerome Rotter,Stephen S Rich,Sina A Gharib,Traci Mae Bartz,Peter Y Liu,Han Chen,Myriam Fornage,Lifang Hou,Daniel Levy,Alanna Morrison, Heather M Ochs-Balcom,Bruce M. Psaty,Peter WF Wilson,Kelly Cho,Allan I Pack,Hanna M Ollila,Susan Redline,Daniel J Gottlieb,Tamar Sofer, FinnGen, the Trans-Omics in Precision Medicine Consortium,the VA Million Veteran Program

medrxiv（2024）

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A Genetic Association Study of Circulating Coagulation Factor VIII and Von Willebrand Factor Levels

Paul S. de Vries,Paula Reventun,Michael R. Brown,Adam S. Heath,Jennifer E. Huffman,Ngoc-Quynh Le,Allison Bebo,Jennifer A. Brody,Gerard Temprano-Sagrera,Laura M. Raffield,Ayse Bilge Ozel,Florian Thibord,Deepti Jain,Joshua P. Lewis,Benjamin A. T. Rodriguez,Nathan Pankratz,Kent D. Taylor,Ozren Polasek,Ming-Huei Chen,Lisa R. Yanek,German D. Carrasquilla,Riccardo E. Marioni,Marcus E. Kleber,David-Alexandre Tregouet,Jie Yao,Ruifang Li-Gao,Peter K. Joshi,Stella Trompet, Angel Martinez-Perez,Mohsen Ghanbari,Tom E. Howard,Alex P. Reiner,Marios Arvanitis,Kathleen A. Ryan,Traci M. Bartz,Igor Rudan,Nauder Faraday,Allan Linneberg,Lynette Ekunwe,Gail Davies,Graciela E. Delgado,Pierre Suchon,Xiuqing Guo,Frits R. Rosendaal,Lucija Klaric,Raymond Noordam, Frank van Rooij,Joanne E. Curran,Marsha M. Wheeler,William O. Osburn,Jeffrey R. O'Connell, Eric Boerwinkle,Andrew Beswick,Bruce M. Psaty,Ivana Kolcic,Juan Carlos Souto,Lewis C. Becker,Torben Hansen,Margaret F. Doyle,Sarah E. Harris,Angela P. Moissl,Jean-Francois Deleuze,Stephen S. Rich,Astrid van Hylckama Vlieg, Harry Campbell,David J. Stott,Jose Manuel Soria,Moniek P. M. de Maat,Laura Almasy, Lawrence C. Brody,Paul L. Auer,Braxton D. Mitchell, Yoav Ben-Shlomo,Myriam Fornage,Caroline Hayward,Rasika A. Mathias, Tuomas O. Kilpelaeinen,Leslie A. Lange,Simon R. Cox,Winfried Maerz,Pierre-Emmanuel Morange,Jerome I. Rotter,Dennis O. Mook-Kanamori,James F. Wilson,Pim van der Harst, J. Wouter Jukema, M. Arfan Ikram,John Blangero,Charles Kooperberg,Karl C. Desch,Andrew D. Johnson,Maria Sabater-Lleal,Charles J. Lowenstein,Nicholas L. Smith,Alanna C. Morrison

BLOODno. 18 (2024): 1845-1855

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Factors Which Modulate Platelet Reactivity As Measured by Five Assay Platforms in 3,429 Individuals

Research and Practice in Thrombosis and Haemostasisno. 3 (2024): 102406-102406

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