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个人简介
Friedman studies the molecular and neural mechanisms that regulate food intake and body weight. Genetic studies in mice led to the identification of leptin, a hormone made by fat tissue that plays a key role in controlling appetite and weight. His current work explores the mechanisms by which leptin regulates energy balance and seeks to identify other key regulators of body weight.
Leptin maintains body weight within a relatively narrow range. Increased fat mass increases leptin levels, which in turn reduces body weight; decreased fat mass decreases leptin levels and increases body weight. Defects in the leptin gene are associated with severe obesity, and leptin treatment normalizes weight in these patients. Leptin also improves the severe diabetes and abnormal lipids in patients with lipodystrophy, and is now an FDA-approved treatment for this condition.
Leptin maintains body weight within a relatively narrow range. Increased fat mass increases leptin levels, which in turn reduces body weight; decreased fat mass decreases leptin levels and increases body weight. Defects in the leptin gene are associated with severe obesity, and leptin treatment normalizes weight in these patients. Leptin also improves the severe diabetes and abnormal lipids in patients with lipodystrophy, and is now an FDA-approved treatment for this condition.
研究兴趣
论文共 413 篇作者统计合作学者相似作者
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Hui Wang,Timothy S. Chang,Beth A. Dombroski,Po-Liang Cheng, Vishakha Patil, Leopoldo Valiente-Banuet,Kurt Farrell,Catriona Mclean,Laura Molina-Porcel,Alex Rajput,Peter Paul De Deyn,Nathalie Le Bastard,Marla Gearing,Laura Donker Kaat,John C. Van Swieten,Elise Dopper,Bernardino F. Ghetti,Kathy L. Newell,Claire Troakes, Justo G. de Yébenes,Alberto Rábano-Gutierrez,Tina Meller, Wolfgang H. Oertel,Gesine Respondek,Maria Stamelou,Thomas Arzberger,Sigrun Roeber,Ulrich Müller,Franziska Hopfner,Pau Pastor,Alexis Brice,Alexandra Durr,Isabelle Le Ber,Thomas G. Beach,Geidy E. Serrano,Lili-Naz Hazrati,Irene Litvan,Rosa Rademakers,Owen A. Ross,Douglas Galasko,Adam L. Boxer, Bruce L. Miller,Willian W. Seeley, Vivanna M. Van Deerlin,Edward B. Lee,Charles L. White,Huw Morris,Rohan de Silva,John F. Crary,Alison M. Goate,Jeffrey S. Friedman,Yuk Yee Leung,Giovanni Coppola,Adam C. Naj,Li-San Wang,Clifton Dalgard,Dennis W. Dickson,Günter U. Höglinger,Gerard D. Schellenberg,Daniel H. Geschwind,Wan-Ping Lee
medRxiv the preprint server for health sciences (2024)
Journal of Plastic, Reconstructive & Aesthetic Surgery (2024): 249-257
Santiago R Unda,Lisa E Pomeranz,Roberta Marongiu,Xiaofei Yu,Leah Kelly,Gholamreza Hassanzadeh,Henrik Molina,George Vaisey,Putianqi Wang,Jonathan P Dyke,Edward K Fung,Logan Grosenick, Rick Zirkel,Aldana M Antoniazzi,Sofya Norman,Conor M Liston,Chris Schaffer,Nozomi Nishimura,Sarah A Stanley,Jeffrey M Friedman,Michael G Kaplitt
bioRxiv the preprint server for biology (2024)
Nature (2024)
Han L Tan,Luping Yin, Yuqi Tan, Jessica Ivanov,Kaja Plucinska,Anoj Ilanges,Brian R Herb,Putianqi Wang,Christin Kosse,Paul Cohen,Dayu Lin,Jeffrey M Friedman
Nature (2024)
Andrés R Muñoz-Rojas, Adam C Wang, Lisa E Pomeranz, Elizabeth L Reizis, Heather W Stout-Delgado, Ileana C Miranda, Krishnan Rajagopalan, Tadiwanashe Gwatiringa, Roger R Fan, Ahmad A Huda, Neha Maskey, Roseline P Olumuyide, Aryan S Patel,Jeffrey M Friedman,Diane Mathis, Kartik N Rajagopalan
The Journal of clinical investigation (2024)
Hui Wang,Timothy S Chang,Beth A Dombroski,Po-Liang Cheng,Ya-Qin Si,Albert Tucci, Vishakha Patil, Leopoldo Valiente-Banuet,Kurt Farrell,Catriona Mclean,Laura Molina-Porcel,Rajput Alex,Peter Paul De Deyn,Nathalie Le Bastard,Marla Gearing,Laura Donker Kaat,John C Van Swieten,Elise Dopper,Bernardino F Ghetti,Kathy L Newell,Claire Troakes, Justo G de Yébenes,Alberto Rábano-Gutierrez,Tina Meller, Wolfgang H Oertel,Gesine Respondek,Maria Stamelou,Thomas Arzberger,Sigrun Roeber,Ulrich Müller,Franziska Hopfner,Pau Pastor,Alexis Brice,Alexandra Durr,Isabelle Le Ber,Thomas G Beach,Geidy E Serrano,Lili-Naz Hazrati,Irene Litvan,Rosa Rademakers,Owen A Ross,Douglas Galasko,Adam L Boxer, Bruce L Miller,Willian W Seeley,Vivianna M Van Deerlin,Edward B Lee,Charles L White,Huw R Morris,Rohan de Silva,John F Crary,Alison M Goate,Jeffrey S Friedman,Yuk Yee Leung,Giovanni Coppola,Adam C Naj,Li-San Wang,Dennis W Dickson,Günter U Höglinger,Jung-Ying Tzeng,Daniel H Geschwind,Gerard D Schellenberg,Wan-Ping Lee
medRxiv (Cold Spring Harbor Laboratory) (2024)
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作者统计
#Papers: 412
#Citation: 99156
H-Index: 101
G-Index: 314
Sociability: 8
Diversity: 0
Activity: 2
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