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The long-term goal of my lab is to develop immunotherapies for leukemia and other hematological diseases through an understanding of T-cell immunity against hematopoietic progenitors. Our central hypothesis is that T-cells target and eliminate these progenitors by recognizing determinants of self-antigens when tolerance has been reversed by aberrant self-antigen expression. As models, we have studied myeloid leukemia and MDS and have found that CD8 lymphocytes recognized the HLA-A2-restricted PR1 peptide, derived from both P3 and NE, due to aberrant subcellular localization and over-expression.
The long-term goal of my lab is to develop immunotherapies for leukemia and other hematological diseases through an understanding of T-cell immunity against hematopoietic progenitors. Our central hypothesis is that T-cells target and eliminate these progenitors by recognizing determinants of self-antigens when tolerance has been reversed by aberrant self-antigen expression. As models, we have studied myeloid leukemia and MDS and have found that CD8 lymphocytes recognized the HLA-A2-restricted PR1 peptide, derived from both P3 and NE, due to aberrant subcellular localization and over-expression.
研究兴趣
论文共 435 篇作者统计合作学者相似作者
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crossref(2024)
crossref(2024)
Eiko Hayase,Tomo Hayase,Akash Mukherjee, Stuart C. Stinson,Mohamed A. Jamal, Miriam R. Ortega,Christopher A. Sanchez,Saira S. Ahmed,Jennifer L. Karmouch,Chia-Chi Chang,Ivonne I. Flores,Lauren K. Mcdaniel,Alexandria N. Brown,Rawan K. El-Himri,Valerie A. Chapa,Lin Tan,Bao Q. Tran, Yao Xiao, Christopher Fan,Dung Pham, Taylor M. Halsey, Yimei Jin, Wen-Bin Tsai, Rishika Prasad, Israel K. Glover, Altai Enkhbayar, Aqsa Mohammed, Maren Schmiester, Katherine Y. King, Robert A. Britton,Pavan Reddy, Matthew C. Wong, Nadim J. Ajami, Jennifer A. Wargo, Samuel Shelburne, Pablo C. Okhuysen,Chen Liu, Stephanie W. Fowler, Margaret E. Conner, Zoe Katsamakis, Natalie Smith, Marina Burgos da Silva, Doris M. Ponce, Jonathan U. Peled, Marcel R. M. van den Brink, Christine B. Peterson,Gabriela Rondon,Jeffrey J. Molldrem, Richard E. Champlin, Elizabeth J. Shpall, Philip L. Lorenzi, Rohtesh S. Mehta, Eric C. Martens,Amin M. Alousi, Robert R. Jenq
CELL HOST & MICROBEno. 9 (2024)
Ho (Brandon) Ngai, Dan Wang, Yibin Chen, Xizeng Mao,Shoudan Liang, Yanqing Huang,Celine Kerros, Luca Zammataro, Priya Koppikar, Noah Tubo,Jeffrey J Molldrem
Regular and Young Investigator Award Abstracts (2024)
crossref(2024)
crossref(2024)
Yimei Jin,Takahiko Miyama,Alexandria Brown,Tomo Hayase,Xingzhi Song,Anand K. Singh,Licai Huang,Ivonne I. Flores,Lauren K. McDaniel,Israel Glover,Taylor M. Halsey,Rishika Prasad,Valerie Chapa,Saira Ahmed,Jianhua Zhang,Kunal Rai,Christine B. Peterson,Gregory Lizee,Jennifer Karmouch,Eiko Hayase,Jeffrey J. Molldrem,Chia-Chi Chang,Wen-Bin Tsai,Robert R. Jenq
Cancer Immunology Research (2024)
LEUKEMIAno. 1 (2024): 226-226
Anne V Philips,Celine Kerros, Helen Hong, Chunhua Shi, Jason Allen, Noah Tubo, Ho (Brandon) Ngai, Ling Yu, Rong Cai, Rolando Vedia, Lisa St John, Gheath Alatrash,Jeffrey J Molldrem
Regular and Young Investigator Award Abstracts (2024)
crossref(2024)
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作者统计
#Papers: 435
#Citation: 13060
H-Index: 53
G-Index: 110
Sociability: 7
Diversity: 2
Activity: 112
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