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职业迁徙
个人简介
Research in our laboratory is directed toward the design and synthesis of both natural products and molecules of design (unnatural products) with important structural and/or biological properties. For over two decades, my laboratory focused on the development of new methodology in organic synthesis and the application of this methodology to the synthesis of naturally occurring compounds with important biological activity. During this period, we developed the intramolecular dioxenone and intramolecular vinylogous amide photocycloadditions (J. Winkler, C. Mazur, and F. Liotta, "[2+2]Photocycloaddition-Fragmentation Strategies for the Synthesis of Natural and Unnatural Products,” Chem. Rev. 1995, 95, 2003-2020) and used these reactions to achieve the first total syntheses of the natural products manzamine A (J. Winkler, J. Axten, "The First Total Syntheses of Ircinol A, Ircinal A, and Manzamines A and D," J. Am. Chem. Soc. 1998, 120, 6425-6426), saudin (J. Winkler, E. Doherty, "The First Total Synthesis of (+)-Saudin"") and ingenol (“The first total synthesis of (+/-)-ingenol,” J. Am. Chem. Soc. 2002, 124, 9726-9728).
Recent work in the Winkler Laboratory involves both the synthesis of natural and unnatural products, i.e., molecules of Nature and molecules of design that are intended to have particular biological and/or structural properties, as well as collaborative efforts with biomedical scientists at the University of Pennsylvania School of Medicine (SOM), the Childrens’ Hospital of Philadelphia (CHOP) and the Wistar Institute to develop novel chemical substances with drug-like properties.
Recent work in the Winkler Laboratory involves both the synthesis of natural and unnatural products, i.e., molecules of Nature and molecules of design that are intended to have particular biological and/or structural properties, as well as collaborative efforts with biomedical scientists at the University of Pennsylvania School of Medicine (SOM), the Childrens’ Hospital of Philadelphia (CHOP) and the Wistar Institute to develop novel chemical substances with drug-like properties.
研究兴趣
论文共 124 篇作者统计合作学者相似作者
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Abibatou Ndoye,Anna Budina-Kolomets,Curtis H. Kugel,Marie R. Webster,Amanpreet Kaur,Reeti Behera,Vito W. Rebecca,Ling Li,Patricia A. Brafford,Qin Liu,Y.N. Vashisht Gopal,Michael A. Davies,Gordon B. Mills,Xiaowei Xu,Hong Wu,Meenhard Herlyn,Michael C. Nicastri,Jeffrey D. Winkler,Maria S. Soengas,Ravi K. Amaravadi,Maureen E. Murphy,Ashani T. Weeraratna
crossref(2023)
Vito W. Rebecca,Michael C. Nicastri,Noel McLaughlin,Colin Fennelly,Quentin McAfee,Amruta Ronghe,Michel Nofal,Chun-Yan Lim,Eric Witze,Cynthia I. Chude,Gao Zhang,Gretchen M. Alicea,Shengfu Piao,Sengottuvelan Murugan,Rani Ojha,Samuel M. Levi,Zhi Wei,Julie S. Barber-Rotenberg,Maureen E. Murphy,Gordon B. Mills,Yiling Lu,Joshua Rabinowitz,Ronen Marmorstein,Qin Liu,Shujing Liu,Xiaowei Xu,Meenhard Herlyn,Roberto Zoncu,Donita C. Brady,David W. Speicher,Jeffrey D. Winkler,Ravi K. Amaravadi
crossref(2023)
Vito W. Rebecca,Michael C. Nicastri,Colin Fennelly,Cynthia I. Chude,Julie S. Barber-Rotenberg,Amruta Ronghe,Quentin McAfee,Noel P. McLaughlin,Gao Zhang,Aaron R. Goldman,Rani Ojha,Shengfu Piao,Estela Noguera-Ortega,Alessandra Martorella,Gretchen M. Alicea,Jennifer J. Lee,Lynn M. Schuchter,Xiaowei Xu,Meenhard Herlyn,Ronen Marmorstein,Phyllis A. Gimotty,David W. Speicher,Jeffrey D. Winkler,Ravi K. Amaravadi
openalex(2023)
bioRxiv (Cold Spring Harbor Laboratory) (2023)
Cancer researchno. 12_Supplement (2022): 217-217
Gaurav Sharma,Rani Ojha,Estela Noguera-Ortega,Vito W. Rebecca,John Attanasio,Shujing Liu,Shengfu Piao,Jennifer J. Lee,Michael C. Nicastri,Sandra L. Harper,Amruta Ronghe,Vaibhav Jain,Jeffrey D. Winkler,David W. Speicher,Jerome Mastio,Phyllis A. Gimotty, Xiaowei Xu,E. John Wherry,Dmitry I. Gabrilovich,Ravi K. Amaravadi
Gaurav Sharma,Rani Ojha,Estela Noguera-Ortega,Vito W. Rebecca,John Attanasio,Shujing Liu,Shengfu Piao,Jennifer J. Lee,Michael C. Nicastri,Sandra L. Harper,Amruta Ronghe,Vaibhav Jain,Jeffrey D. Winkler,David W. Speicher,Jerome Mastio,Phyllis A. Gimotty, Xiaowei Xu,E. John Wherry,Dmitry Gabrilovich,Ravi K. Amaravadi
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作者统计
#Papers: 124
#Citation: 4217
H-Index: 36
G-Index: 64
Sociability: 6
Diversity: 3
Activity: 45
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