His clinical research interests are in the field of venous thromboembolism, of coronary artery disease, acute coronary syndromes and atrial fibrillation. He has authored or co-authored over 280 manuscripts in peer-reviewed journals including three European Society of Cardiology guidelines on the management of acute coronary syndromes and of pulmonary embolism. He was awarded the American College of Cardiology Maseri-Florio Prize in 2009.