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职业迁徙
个人简介
Post-Doc (1983-1985): Brookhaven National Laboratory。 Ph.D. (June, 1984): California Institute of Technology。 B.S. (June, 1978): Stanford University。
1985-1987: Assistant Scientist, Brookhaven National Laboratory。 1987-1990: Associate Scientist, Brookhaven National Laboratory。 1990-: Member of the Beckman Institute, California Institute of Technology。 1990-: Director, Beckman Institute Laser Center, California Institute of Technology。 2002, 2004, 2009-: Lecturer, Division of Chemistry and Chemical Engineering, California Institute of Technology。 2003: Lecturer, Department of Chemistry, University of California, Irvine。 2008-: Faculty Associate in Chemistry, California Institute of Technology。
Awards and Honors:
Honda-Fujishima Lectureship Award, Japanese Photochemistry Association (2010)。
My research program is an interdisciplinary experimental effort aimed at fundamental
problems in biophysics, biochemistry, and inorganic chemistry. Steady-state and timeresolved
laser spectroscopies play a central role in the development of new methods for
studying chemical kinetics and reactive intermediates. In the mid 1990s, we initiated a
research program to investigate the kinetics of metalloprotein folding triggered by electron
transfer (ET). We demonstrated that this approach can be applied to a wide variety of redoxactive
proteins, permitting investigations of folding dynamics on microsecond (and faster)
timescales. We also employ light-driven electron-transfer chemistry to study redox enzymes.
Targets include electron transfer proteins (cytochromes, blue copper proteins), as well as
multielectron redox enzymes (cytochrome P450, nitric oxide synthase). The objective of these
investigations is to develop deeper insight into the mechanisms of long-range electron transfer
and multi-electron redox reactions. One of the primary challenges in solar fuels research is to
couple photodriven one-electron transfer processes to the multielectron redox chemistry that is
required for long-term energy storage. We are employing laser flash-quench triggering
methods, and time-resolved spectroscopic monitoring to map out the key steps as well as
identify reactive intermediates in these critical transformations.
Total Publications:
180 Publications。
研究兴趣
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Accounts of chemical researchno. 14 (2023): 1978-1989
FEBS Lettersno. 1 (2023): 59-64
Journal of Inorganic Biochemistry (2022): 111886
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