基本信息
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Career Trajectory
Bio
Dr. Luke is one of the foremost international investigators in the realm of immuno-oncology, having led clinical trials of immunotherapies including but not limited to anti-PD1/L1, CTLA4, many secondary checkpoints, bispecific approaches (checkpoint, CD3 and cytokine), metabolism modifiers (IDO, A2Ar/CD73/CD39 and arginase), innate agonists of STING, TLRs and oncolytic virus as well as solid tumor cellular therapies (TCRs and CART). In melanoma, Dr. Luke has designed and led two practice changing trials determining the role of anti-PD1 + CTLA4 after initial anti-PD1 failure (compendium listed in the NCCN) and altering the landscape of melanoma oncology practice across dermatology, surgery and medical oncology via establishment of modern adjuvant therapy with anti-PD1 for node negative stage IIB/C disease (leading to FDA/EMA approval). Dr. Luke has been a major contributor toward the investigation of radiation and the microbiome in relation to cancer immunotherapy. Dr. Luke’s major translational research focus leverages large scale informatics to advance cancer immunotherapy. Dr. Luke has on-going NIH funding for his translational research laboratory which focuses on tumor-intrinsic mechanisms of immune exclusion and designing next generation immunotherapy approaches to overcome them.
Research Interests
Papers共 425 篇Author StatisticsCo-AuthorSimilar Experts
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Nikhil Khushalani,Patrick A. Ott,Robert L. Ferris,Tina Cascone,Dirk Schadendorf,Dung T. Le,Manish R. Sharma,Fabrice Barlesi,William Sharfman,Jason J. Luke,Ignacio Melero,Deanne Lathers,Jaclyn Neely,Satyendra Suryawanshi, Abanti Sanyal, James L. Holloway, Rasika Suryawanshi,Scott Ely,Neil H. Segal
crossref(2024)
JOURNAL FOR IMMUNOTHERAPY OF CANCERno. 6 (2024)
Current Oncology Reportsno. 7 (2024): 826-839
Martin Wermke, Winfried Alsdorf, Dejka M Araujo, Manik Chatterjee, Oliver Ebert, Leonel Hernandez-Aya, Norbert Hilf, Tobias AW Holderried,Amir A Jazaeri, M Alper Kursunel, Andrea Mayer-Mokler, Regina Mendrzyk,Ali Mohamed,Sapna Patel, Ran Reshef, Apostolia Maria Tsimberidou,Steffen Walter, Toni Weinschenk,Jason J Luke, Cedrik M Britten
Regular and Young Investigator Award Abstracts (2024)
Diwakar Davar, Robert M Morrison, Amiran K Dzutsev, Arivarasan Karunamurthy, Joe-Marc Chauvin, Florent Amatore, Julie S Deutsch, Rodrigo X Das Neves, Richard R Rodrigues, John A McCulloch,Hong Wang, Douglas J Hartman, Jonathan H Badger, Miriam R Fernandes, Yulong Bai, Jie Sun, Alicia M Cole, Poonam Aggarwal, Jennifer R Fang, Christopher Deitrick, Riyue Bao, Umamaheswar Duvvuri, Shaum S Sridharan, Seungwon W Kim, Haroon A Choudry, Matthew P Holtzman, James F Pingpank, James Patrick O'Toole, Richelle DeBlasio, Yang Jin, Quanquan Ding,Wentao Gao, Christopher Groetsch,Ornella Pagliano,Amy Rose, Corey Urban, Jagjit Singh, Prajan Divarkar,David Mauro, Dmitri Bobilev, James Wooldridge,Arthur M Krieg, Matthew G Fury, Jeffrey R Whiteaker,Lei Zhao, Amanda G Paulovich, Yana G Najjar,Jason J Luke,John M Kirkwood, Janis M Taube,Hyun Jung Park,Giorgio Trinchieri, Hassane M Zarour
Cancer cellno. 11 (2024): 1898-1918.e12
Devalingam Mahalingam, Mateusz Opyrchal, Justin C Moser, Ildefonso Rodriguez Rivera, Mehmet A Bilen, Christos Fountzilas,Brendan D Curti,Kristin Morris, Christopher J Nirschl, Shawn Ironside, Saero Park, Marissa Bruno, Paul Windt, Kulandayan K Subramanian, Sameer S Chopra, Randi E Isaacs,Jason J Luke
Regular and Young Investigator Award Abstracts (2024)
Kara M. Schenk,Julie Stein Deutsch,Sunandana Chandra,Diwakar Davar,Zeynep Eroglu,Nikhil I. Khushalani,Jason J. Luke,Patrick A. Ott,Jeffrey A. Sosman,Vikram Aggarwal,Megan D. Schollenberger,William H. Sharfman,Kristin P. Bibee,Jeffrey F. Scott,Manisha J. Loss,Hao Wang,Hanfei Qi,Elad Sharon,Howard Streicher,Helen X. Chen,Robert N. Woodward,Serena M. Bagnasco,Janis M. Taube,Suzanne L. Topalian,Daniel C. Brennan,Evan J. Lipson
JOURNAL OF CLINICAL ONCOLOGYno. 9 (2024)
Julia Foldi, Sarina A. Piha-Paul,Liza C. Villaruz,Heather L. McArthur,Madeline Olson, Euodia Jonathan, Brian Ostrander,Kartik Krishnan,Jason J. Luke
JOURNAL OF CLINICAL ONCOLOGYno. 16 (2024)
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Author Statistics
#Papers: 427
#Citation: 13441
H-Index: 49
G-Index: 112
Sociability: 8
Diversity: 3
Activity: 499
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