The research program includes investigation of radiation sensitizers, antiangiogenesis agents, hypoxia, and molecular and cellular imaging. Research focused on enhancing radiation and chemotherapeutic response is typically done both in perfused cells and subsequently in vivo. It focuses on monitoring the biochemical effects induced by novel drugs and evaluating the effects of dose and time for optimization of drug–drug or drug–radiation interaction. Clinical studies are focused on obtaining diagnostic information (1H spectroscopy studies of prostate and brain), prognostic data, and evaluating response to standard and novel antineoplastic agents.