Dr. Dennis’ major research program focuses on the structure and functions of protein Asn (N)-glycosylation in development and disease using genetic and biochemical methods with mice, C. elegans and human experimental models. N-glycans on receptor kinases and nutrient transporters are required for proper folding of these glycoproteins in the endoplasmic reticulum, and subsequently, modification to the N-glycans in the Golgi regulate their activities at the cell surface.