Research Summary As a surgeon-scientist Bainbridge's aim is to reduce blindness by developing new treatments for retinal diseases. He collaborates widely in multidisciplinary research programmes to develop new molecular and cellular therapies. His own programme of research extends from the laboratory investigation of mechanisms of retinal disease in experimental models, through preclinical development of novel therapies, to clinical trials of new medical and surgical interventions. Having performed the World’s first gene replacement surgery for inherited blindness (Bainbridge et al NEJM 2008) he demonstrated proof of concept for sustained benefit (Bainbridge et al NEJM 2015). His contribution has been recognised by numerous prizes including in 2008 the US Foundation Fighting Blindness and in 2018 the Champalimaud Vision Award, which is the world’s largest prize in vision research.