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Realizing the few options available for kidney cancer patients, Dr. Brugarolas decided to dedicate his life to finding a cure. Following completion of medical school in his home country of Spain in 1993, he came to the U.S. seeking to better understand the biological underpinnings of cancer. As a graduate student at MIT, his research in the laboratory of Tyler Jacks, Ph.D. provided fundamental understanding on how cell proliferation is regulated by both external and internal cues. In a series of highly-cited manuscripts in Nature, Proceedings of the National Academy of Sciences, and The Journal of Cell Biology, he reported that growth signals control the cell cycle by modulating the activity of CDK4 and CDK2, and that constitutive activation of these kinases was sufficient to confer cell proliferation autonomy. His studies revealed that the so-called guardian of the genome, the p53 protein, imposed a cell cycle arrest through p21, but that p21 was dispensable for p53-mediated cell death, and provided insight into the mechanism of p21 action.
研究兴趣
论文共 293 篇作者统计合作学者相似作者
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Dazhi Wang,Iqbal Mahmud, Vijay S Thakur,Sze Kiat Tan,Daniel G Isom, David B Lombard,Mark L Gonzalgo,Oleksandr N Kryvenko,Philip L Lorenzi,Vanina T Tcheuyap,James Brugarolas,Scott M Welford
Dylan Calhoon, Lingjie Sang,Divya Bezwada, Nathaniel Kim,Amrita Basu, Sheng-Chieh Hsu, Anastasia Pimentel, Bailey Brooks, Konnor La, Ana Paulina Serrano, Daniel L Cassidy,Ling Cai,
bioRxiv : the preprint server for biology (2024)
David Hein,Alana Christie, Hua Zhong, Ellen Araj,James Brugarolas,Lindsay Cowell,Payal Kapur,Andrew Jamieson
Cancer Researchno. 6_Supplement (2024): 7390-7390
Gopinath Prakasam,Akhilesh Mishra,Alana Christie,Jeffrey Miyata,Deyssy Carrillo,Vanina T Tcheuyap, Hui Ye,Quyen N Do,Yunguan Wang,Oscar Reig Torras,Ramesh Butti,Hua Zhong,
The Journal of clinical investigationno. 7 (2024)
James Brugarolas, Gregory Obara,Kathryn E Beckermann,Brian Rini,Elaine T Lam,James Hamilton,Thomas Schluep,Min Yi,So Wong, Zhongping Lily Mao, Erick Gamelin,Nizar M Tannir
Payal Kapur,Hua Zhong, Daniel Le, Ratna Mukhopadhyay, Jeffrey Miyata, Deyssy Carrillo,Dinesh Rakheja,Satwik Rajaram,Steffen Durinck,Zora Modrusan,James Brugarolas
JCI insightno. 10 (2024)
Lianxin Hu, Yanfeng Zhang,Lei Guo,Hua Zhong,Ling Xie, Jin Zhou,Chengheng Liao, Hongwei Yao, Jun Fang, Hongyi Liu,Cheng Zhang,Hui Zhang,
MOLECULAR CELLno. 4 (2024): 776-790.e5
crossref(2023)
Journal for immunotherapy of cancerno. 3 (2023): e006361-e006361
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