Chaim O. Jacob

基本信息

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职业迁徙

个人简介

Dr. Jacob's research interests include genetics and pathogenesis of systemic lupus erythematosus (SLE). He continues his groundbreaking work in discovering and characterizing new genes important to the development of SLE.

研究兴趣

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Lupus-prone NZM2328 Mice Exhibit Enhanced UV-induced Myeloid Cell Recruitment and Activation in a Type I Interferon Dependent Manner

Mitra P. Maz,Alayka L. Reddy,Celine C. Berthier,Lam C. Tsoi,Deborah J. Colesa,Sonya J. Wolf, Hong Shi,Shannon N. Loftus, Rezvan Moallemian, Rachael Bogle,Matthias Kretzler,Chaim O. Jacob,Johann E. Gudjonsson,J. Michelle Kahlenberg

JOURNAL OF AUTOIMMUNITY (2024)

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Lupus-associated NCF2 variant p.R395W in the NADPH oxidase 2 complex results in a reduced production of reactive oxygen species by myeloid cells

Zhimin Song,Dae-Goon Yoo,Rachel A. Idol,Emilia Alina Barbu,Chaim O. Jacob,Mary C. Dinauer

Frontiers in Lupus (2023)

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Context-dependent Induction of Autoimmunity by TNF Signaling Deficiency

Tam D. Quach,Weiqing Huang,Ranjit Sahu,Catherine M. M. Diadhiou,Chirag Raparia, Roshawn Johnson,Tung Ming Leung,Susan Malkiel, Peta Gay Ricketts,Stefania Gallucci,Cagla Tukel,Chaim O. Jacob,Martin L. Lesser,Yong-Rui Zou,Anne Davidson

JCI Insight（2022）

引用1浏览0WOS引用

New Endothelial Mechanisms in Glomerular (patho)biology and Proteinuria Development Captured by Intravital Multiphoton Imaging

Georgina Gyarmati,Chaim O. Jacob,János Peti-Peterdi

Frontiers in medicine（2021）

引用3浏览0引用

Inhibition of B Cell Activation Following in Vivo Co-Engagement of B Cell Antigen Receptor and Fcγ Receptor IIb in Non-Autoimmune-prone and SLE-prone Mice

Seung Y. Chu,Erik Pong,Christine Bonzon,Ning Yu,Chaim O. Jacob,Samantha A. Chalmers,Chaim Putterman,David E. Szymkowski,William Stohl

Journal of translational autoimmunity（2021）

引用9浏览0WOS引用

Essential Role and Therapeutic Targeting of the Glomerular Endothelial Glycocalyx in Lupus Nephritis

Hiroyuki Kadoya,Ning Yu,Ina Maria Schiessl,Anne Riquier-Brison,Georgina Gyarmati,Dorinne Desposito,Kengo Kidokoro,Matthew J. Butler,Chaim O. Jacob,Janos Peti-Peterdi

JCI insight（2020）

引用19浏览0WOS引用

On the genetics and immunopathogenesis of COVID-19

Chaim Oscar Jacob

CLINICAL IMMUNOLOGY（2020）

引用33浏览0WOS引用

Tnf Deficiency Induces Breach Of B Cell Tolerance By Altering The Homeostasis Of The Regulatory Signals In Activated B Cells Of Lupus Prone Mice

Tam D. Quach,Catherine M. M. Diadhiou,Chirag Raparia,Shani Martinez,Haiou Tao,Cagla Tukel,Chaim O. Jacob,Anne Davidson

JOURNAL OF IMMUNOLOGY（2020）

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论文共 256 篇作者统计合作学者相似作者