基本信息
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Career Trajectory
Bio
Description of Research Expertise
Integrin function is essential for normal platelet adhesion and aggregation and participates i n the formation of the arterial thrombi that are responsible for heart attacks and strokes. The activation state of platelet integrins is regulated by platelet agonists, but the structural basis for this regulation is not known. Our studies indicate that helix-helix interactions involving the transmembrane and membrane-proximal cytoplasmic domain segments play an essential role in regulating the function of both beta 1 and beta 3 integrins. The current focus of the laboratory is to use biophysical and molecular biologic techniques to characterize these interactions in detail and to use this information to design potential anti-thrombotic agents.
Description of Clinical Expertise
General Hematology, Internal Medicine, Hemostasis, and Thrombosis
Research Interests
Papers共 264 篇Author StatisticsCo-AuthorSimilar Experts
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Author Statistics
#Papers: 264
#Citation: 10603
H-Index: 53
G-Index: 100
Sociability: 6
Diversity: 0
Activity: 0
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