Dr. Rothstein focuses on neuromuscular diseases, with a particular concentration on Amyotrophic Lateral Sclerosis (ALS) and on roles of glutamate transporters in neurodegenerative disease. His laboratory is funded through the National Institutes of Health, the Muscular Dystrophy Association, the ALS Association, and Project A.L.S. He has been the principal and/or local investigator in eight national and international trials in ALS. Dr. Rothstein has been granted 2 patents and currently has 14 patents under review.