Josh started his career in industry working on the development of Illumina DNA sequencing platforms including the HiSeq 2000 and MiSeq. After meeting Nick Loman though the MiSeq early access program he moved to Birmingham to start a PhD in Biological Sciences in 2012. During his PhD Josh applied whole-genome sequencing to investigate hospital outbreaks of Pseudomonas aeruginosa and Salmonella enterica. He later travelled to Guinea in West Africa to establish the first real-time, genomic surveillance laboratory which has since become the gold-standard in outbreak management. He has also travelled to Brazil, DRC and São Tomé with a lab-in-a-suitcase for research purposes or WHO deployments. He develops the primalscheme primer design software and the ARTIC protocol for amplicon sequencing using nanopore, the most popular method for SARS-CoV-2 sequencing with over 1M genomes produced. In 2019 he was awarded a 7-year UKRI FLF fellowship to establish his own lab. The project OneAMR aims to develop rapid, portable genomics for the prediction of antibiotic resistance, a serious threat which has rendered many existing antibiotics ineffective. He chairs the sequencing working group for the COVID-19 Genomics UK Consortium, the world leaders in genomic surveillance of SARS-CoV-2.