Interests
As a clinician specialising within Neurointensive care my research interests are focused on describing the pathophysiology of head injury and optimising patient outcome. Using the combined facilities of the Wolfson Brain Imaging and Neurosciences Critical Care Unit at Addenbrooke's Hospital patients undergo structural and functional imaging studies using positron emission tomography and magnetic resonance imaging. I have used such imaging tools to define the incidence, temporal evolution and impact on outcome of cerebral ischaemia following head injury. Other work has addressed the impact of clinical interventions aimed at controlling intracranial pressure such as hyperventilation and elevation of cerebral perfusion pressure. Current research is aimed at using imaging techniques to define the temporal pattern and metabolic correlates of neuronal loss after human head injury. Such data will be crucial in the development and implementation of successful neuroprotective therapies.