J.H. Frederik Falkenburg mostly deals with Immunology, Cytotoxic T cell, Minor histocompatibility antigen, Antigen and T cell. The concepts of his Immunology study are interwoven with issues in Transplantation and Donor lymphocyte infusion. His Transplantation research includes themes of Stem cell and Virology.

His work carried out in the field of Cytotoxic T cell brings together such families of science as Immunotherapy, CD8 and Cell biology. His biological study deals with issues like Epitope, which deal with fields such as H-Y antigen, Peptide, Antigen presentation and Computational biology. His research investigates the connection between Human leukocyte antigen and topics such as T-cell receptor that intersect with issues in Molecular biology, Adoptive cell transfer and T lymphocyte.