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Research and Scholarship
Research in the Du Bois laboratory spans reaction methods development, natural product synthesis, and chemical biology, and draws on expertise in molecular design, molecular recognition, and physical organic chemistry. An outstanding goal of our program has been to develop C–H bond functionalization processes as general methods for organic chemistry, and to demonstrate how such tools can impact the logic of chemical synthesis. A second area of interest focuses on the role of ion channels in electrical conduction and the specific involvement of channel subtypes in the sensation of pain. This work is enabled in part through the advent of small molecule modulators of channel function.
The Du Bois group has described new tactics for the selective conversion of saturated C–H to C–N and C–O bonds. These methods have general utility in synthesis, making possible the single-step incorporation of nitrogen and oxygen functional groups and thus simplifying the process of assembling complex molecules. To date, lab members have employed these versatile oxidation technologies to prepare natural products that include manzacidin A and C, agelastatin, tetrodotoxin, and saxitoxin. Detailed mechanistic studies of metal-catalyzed C–H functionalization reactions are performed in parallel with process development and chemical synthesis. These efforts ultimately give way to advances in catalyst design. A long-standing goal of this program is to identify robust catalyst systems that afford absolute control of reaction selectivity.
Research in the Du Bois laboratory spans reaction methods development, natural product synthesis, and chemical biology, and draws on expertise in molecular design, molecular recognition, and physical organic chemistry. An outstanding goal of our program has been to develop C–H bond functionalization processes as general methods for organic chemistry, and to demonstrate how such tools can impact the logic of chemical synthesis. A second area of interest focuses on the role of ion channels in electrical conduction and the specific involvement of channel subtypes in the sensation of pain. This work is enabled in part through the advent of small molecule modulators of channel function.
The Du Bois group has described new tactics for the selective conversion of saturated C–H to C–N and C–O bonds. These methods have general utility in synthesis, making possible the single-step incorporation of nitrogen and oxygen functional groups and thus simplifying the process of assembling complex molecules. To date, lab members have employed these versatile oxidation technologies to prepare natural products that include manzacidin A and C, agelastatin, tetrodotoxin, and saxitoxin. Detailed mechanistic studies of metal-catalyzed C–H functionalization reactions are performed in parallel with process development and chemical synthesis. These efforts ultimately give way to advances in catalyst design. A long-standing goal of this program is to identify robust catalyst systems that afford absolute control of reaction selectivity.
研究兴趣
论文共 125 篇作者统计合作学者相似作者
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Mengyuan Xu, Torben Neelands, Alexander S. Powers,Yan Liu, Steven D. Miller, Grigore D. Pintilie,J. Du Bois,Ron O. Dror,Wah Chiu,Merritt Maduke
M. Xu, T. Neelands, A.S. Powers, Y. Liu, S. Miller, G. Pintilie,J. Du Bois, R.O. Dror, W. Chiu, M. Maduke
crossref(2024)
JOURNAL OF THE AMERICAN CHEMICAL SOCIETYno. 33 (2024): 23067-23074
STAR protocolsno. 1 (2024): 102792-102792
Cell Chemical Biology (2024)
Darren S. Finkelstein,J. Du Bois
ChemBioChemno. 22 (2023)
Husniye Kantarci, Pablo D. Elvira,Arun P. Thottumkara,Manasi Iyer,Lauren J. Donovan, Micaela Quinn Dugan,Nicholas Ambiel,Emma M. O’Connell,Alejandro Granados,Hong Zeng,Nay L. Saw,Amanda Brosius Lutz,Steven A. Sloan,Erin E. Gray, Khanh V. Tran,Aditi Vichare, Ashley K. Yeh,Alexandra E. Münch, Max Huber,Aditi Agrawal,Maurizio Morri,Mehrdad Shamloo,Thomas Anthony Anderson,Vivianne L. Tawfik,J. Du Bois,J. Bradley Zuchero
biorxiv(2023)
Molecular pharmacologyno. 2 (2022): 106-115
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作者统计
#Papers: 125
#Citation: 7723
H-Index: 41
G-Index: 87
Sociability: 6
Diversity: 0
Activity: 1
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