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职业迁徙
个人简介
Description of Research Expertise
Research Interests
The Rader laboratory is focused on two major themes: 1) novel pathways regulating lipid and lipoprotein metabolism and atherosclerosis inspired by unbiased studies of human genetics; 2) factors regulating the structure and function of high density lipoproteins and the process of reverse cholesterol transport and their relationship to atherosclerosis. A variety of basic cell and molecular laboratory techniques, mouse models, and translational research approaches are used in addressing these questions.
Some examples of ongoing projects are:
1) The roles of sortilin (gene SORT1) and tribbles-1 (gene TRIB1) in lipoprotein metabolism and atherosclerosis. Variants at the SORT1 locus are among the most strongly associated with LDL cholesterol and (coronary artery disease) in the human genome, and variants at the TRIB1 locus are significantly associated with all major plasma lipid traits and CAD. A variety of tissue-specific deleted mouse models, gene targeting in iPS cells with differentiation to hepatocytes, and cell biologic and biochemical approaches are being employed.
2) Functional genomics and mechanistic studies of a number of additional genes at loci significantly associated with lipid and metabolic traits, CAD, or other cardiovascular traits. Most of these genes harbor rare coding variants associated with these traits. In addition to elucidating fundamental mechanisms by which the protein influences relevant biology, the influence of specific mutations on protein structure and function are being explored.
3) Molecular regulation of HDLmetabolism and reverse cholesterol transport using cells, mice, and humans
4) Deep phenotyping of humans with low-frequency and rare variants in genes influencing lipid and cardiovascular traits, including the generation of iPS cells and differentiation to a variety of relevant cell types
Research Interests
The Rader laboratory is focused on two major themes: 1) novel pathways regulating lipid and lipoprotein metabolism and atherosclerosis inspired by unbiased studies of human genetics; 2) factors regulating the structure and function of high density lipoproteins and the process of reverse cholesterol transport and their relationship to atherosclerosis. A variety of basic cell and molecular laboratory techniques, mouse models, and translational research approaches are used in addressing these questions.
Some examples of ongoing projects are:
1) The roles of sortilin (gene SORT1) and tribbles-1 (gene TRIB1) in lipoprotein metabolism and atherosclerosis. Variants at the SORT1 locus are among the most strongly associated with LDL cholesterol and (coronary artery disease) in the human genome, and variants at the TRIB1 locus are significantly associated with all major plasma lipid traits and CAD. A variety of tissue-specific deleted mouse models, gene targeting in iPS cells with differentiation to hepatocytes, and cell biologic and biochemical approaches are being employed.
2) Functional genomics and mechanistic studies of a number of additional genes at loci significantly associated with lipid and metabolic traits, CAD, or other cardiovascular traits. Most of these genes harbor rare coding variants associated with these traits. In addition to elucidating fundamental mechanisms by which the protein influences relevant biology, the influence of specific mutations on protein structure and function are being explored.
3) Molecular regulation of HDLmetabolism and reverse cholesterol transport using cells, mice, and humans
4) Deep phenotyping of humans with low-frequency and rare variants in genes influencing lipid and cardiovascular traits, including the generation of iPS cells and differentiation to a variety of relevant cell types
研究兴趣
论文共 179 篇作者统计合作学者相似作者
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Eleonora Scorletti,Helen Huang,David Zhang,Joseph Park,Florian Kahles, Giorgio Siguro,Kai Markus Schneider, Garret FitzGerald,Rader Daniel,Carolin Schneider
Gastroenterologyno. 5 (2024): S-85-S-86
American journal of preventive cardiology (2023): 100414-100414
Kai Markus Schneider,Carolin V. Schneider, KateTownsend Creasy,Eleonora Scorletti,Marijana Vujkovic,Mara Vell,Daniel J. Rader
Zeitschrift für Gastroenterologie (2023)
Hao Yu Chen,Christian Dina,Aeron Small,Christian M. Shaffer,Rebecca T. Levinson,Anna Helgadóttir,Romain Capoulade,Hans Markus Münter,Andreas Martinsson,Benjamin J. Cairns,Linea C Trudsø,Mary Hoekstra,Hannah A. Burr,Thomas W. Marsh,Scott M. Damrauer,Line Dufresne,Solena Le Scouarnec,David Messika‐Zeitoun,Dilrini K. Ranatunga,Rachel A. Whitmer,Amélie Bonnefond,Garðar Sveinbjörnsson,Ragnar Daníelsen,Davíð O. Arnar,Guðmundur Þorgeirsson,Unnur Þorsteinsdóttir,Daníel F. Guðbjartsson,Hilma Hólm,Jonas Ghouse,Morten S. Olesen,Alex Hørby Christensen,Susan Mikkelsen,Rikke Louise Jacobsen,Joseph Dowsett,Ole Birger Vesterager Pedersen,Christian Erikstrup,Sisse Rye Ostrowski,Regeneron Genetics Center,Christopher J. O’Donnell,Matthew J. Budoff,Vilmundur Guðnason,Wendy S. Post,Jerome I. Rotter,Mark Lathrop,Henning Bundgaard,Bengt Johansson,Johan Ljungberg,Ulf Näslund,Thierry Le Tourneau,J. Gustav Smith,Quinn S. Wells,Stefan Söderberg,Kári Stefánsson,Jean‐Jacques Schott,Daniel J. Rader,R. N. Clarke,James C. Engert,George Thanassoulis
Zenodo (CERN European Organization for Nuclear Research) (2023)
Transactions of the American Nuclear Society - Volume 123 (2020)
Derek Klarin, Emma Busenkell,Renae Judy,Julie Lynch,Krishna Aragam,Mark Chaffin,Mary Haas,Themistocles L Assimes,Jie Huang,Kyung Min Lee,Qing Shao,Jennifer E Huffman,Yunfeng Huang,Yan V Sun,Marijana Vujkovic,Danish Saleheen,Donald R Miller,Peter Reaven,Scott DuVall,William Boden,Saiju Pyarajan,J. Michael Gaziano,John Concato,Daniel J Rader,Kelly Cho,Kyong-Mi Chang,Peter W Wilson,Nicholas L Smith,Christopher J O’Donnell,Philip S Tsao,Sekar Kathiresan,Pradeep Natarajan,Scott M DAMRAUER
Arteriosclerosis, Thrombosis, and Vascular Biologyno. Suppl_1 (2019)
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作者统计
#Papers: 178
#Citation: 14940
H-Index: 39
G-Index: 121
Sociability: 7
Diversity: 2
Activity: 1
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