Research Interests Structural and biophysical methods applied to biomedically-important cellular processes. One focus is the control of miRNA maturation and degradation in the cell, which has relevance for a broad range of cancers, metabolism, inflammation and innate viral immunity. The other main focuses of the lab are membrane pore formation by proteins of the membrane attack complex/perforin and cholesterol-dependent cytolysin family involved in infection, immunity and development; and the regulation of membrane adhesion to other cells at the extracellular matrix.