Dr. Bissonnette has been active in several areas relevant to radiotherapy, including quality assurance and patient safety, high-precision radiotherapy for the brain and the lung, post-graduate education, and monitoring response of locally-advanced lung cancer to combined chemo-radiotherapy using CT, CBCT and PET images. Current research topics include dose reconstruction based on image-guidance images, image-based adaptation of therapy and exploring the use of statistical tools to rationalize and limit the cost of quality control work.