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个人简介
Our research group is an international team of biologists and clinicians with the aim to uncover selected disease mechanisms in pancreatic disease with the ultimate goal of developing novel therapy strategies.
The main three lines of investigation in our laboratory are as follows:
1) Mechanisms of neural invasion and neuropathy in human pancreatic cancer
Co-Investigators: Istvanffy, Wang
Neural invasion is one of hallmarks of human pancreatic cancer and pancreatic neuropathy, and it drastically worsens the prognosis of patients due to early recurrence. We developed novel research tools for simulating neural invasion in 3D culture and, together with our collaboration partners, characterized novel GEMMs of pancreatic cancer that exhibit human-like neural invasion. We currently focus on the role of Schwann cells, stromal cells (i.e. cancer-associate fibroblasts), mesenchymal stem cells, and especially immune cells as potential inducers of neural invasion.
2) Tumor immune profile in locally advanced and resectable pancreatic cancer
Co-Investigators: Istvanffy, Safak, Mota-Reyes
Neoadjuvant therapy has remarkably improved the prognosis of patients with locally advanced pancreatic cancer, who can in ca. 60% of cases become candidates for surgical resection after tumor downsizing. We are applying novel mouse models that allow the application of neoadjuvant therapy similar to the clinical setting, and analyse the immune profile of neoadjuvantly treated versus primary resected pancreatic cancer in simultaneous comparison with human specimens.
3) Pain mechanisms in pancreatitis and pancreatic Cancer
Co-Investigators: Schorn, Safak
By far, the most unpleasant symptom of pancreatitis and pancreatic cancer is severe abdominal and/or back pain. We have recently identified the molecular, neuro-immune mediators of pain in both diseases and are currently performing pre-clinical analgesic trials for more effective pain treatment in pancreatic diseases.
The main three lines of investigation in our laboratory are as follows:
1) Mechanisms of neural invasion and neuropathy in human pancreatic cancer
Co-Investigators: Istvanffy, Wang
Neural invasion is one of hallmarks of human pancreatic cancer and pancreatic neuropathy, and it drastically worsens the prognosis of patients due to early recurrence. We developed novel research tools for simulating neural invasion in 3D culture and, together with our collaboration partners, characterized novel GEMMs of pancreatic cancer that exhibit human-like neural invasion. We currently focus on the role of Schwann cells, stromal cells (i.e. cancer-associate fibroblasts), mesenchymal stem cells, and especially immune cells as potential inducers of neural invasion.
2) Tumor immune profile in locally advanced and resectable pancreatic cancer
Co-Investigators: Istvanffy, Safak, Mota-Reyes
Neoadjuvant therapy has remarkably improved the prognosis of patients with locally advanced pancreatic cancer, who can in ca. 60% of cases become candidates for surgical resection after tumor downsizing. We are applying novel mouse models that allow the application of neoadjuvant therapy similar to the clinical setting, and analyse the immune profile of neoadjuvantly treated versus primary resected pancreatic cancer in simultaneous comparison with human specimens.
3) Pain mechanisms in pancreatitis and pancreatic Cancer
Co-Investigators: Schorn, Safak
By far, the most unpleasant symptom of pancreatitis and pancreatic cancer is severe abdominal and/or back pain. We have recently identified the molecular, neuro-immune mediators of pain in both diseases and are currently performing pre-clinical analgesic trials for more effective pain treatment in pancreatic diseases.
研究兴趣
论文共 357 篇作者统计合作学者相似作者
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FRONTIERS IN IMMUNOLOGY (2024)
M. Ekizce, S. Sığırlı, M. Gökalp, R.R. Ünal, G. Kurtoğlu, E. Arık Sever,H. Asımgil,D. Karakaş,İ.E. Demir,G.O. Ceyhan
HPB (2024)
Christopher Kessler,Francheska Cadacio,Carlo Maurer,Arlett Schäfer,Daniela Schilling,Ihsan E. Demir,Katja Steiger,Roland M. Schmid,Maximilian Reichert, Stephanie E. Combs,Sophie Dobiasch
Radiotherapy and Oncology (2024)
FEBS OPEN BIO (2024): 310-310
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William L Hwang, Ella N Perrault, Alexander Birbrair, Brandi J Mattson,David H Gutmann,Donald J Mabbott,Edna Cukierman,Elizabeth A Repasky,Erica K Sloan, Hui Zong,Ihsan Ekin Demir,Jami L Saloman,Jeremy C Borniger, Jian Hu,Jorg Dietrich,Joshua J Breunig, Kaan Çifcibaşı, Khalil Ali Ahmad Kasm,Manuel Valiente, Max Wintermark,Munjal M Acharya,Nicole N Scheff, Nisha J D'Silva,Paola D Vermeer,Richard J Wong,Sebastien Talbot, Shawn L Hervey-Jumper, Timothy C Wang,Yi Ye,Yuan Pan,Yuri L Bunimovich, Moran Amit
Cancer cell (2024)
Surgeryno. 4 (2024): 1162-1168
Huseyin Erdinc Besikcioglu,Ummugulsum Yurteri,Linhan Ye, Fang Zhang,Alessandra Moretti,Ibrahim Halil Guercinar,Alper Dogruoez,Didem Karakas,Helmut Friess,Guralp Onur Ceyhan,Rouzanna Istvanffy,Ihsan Ekin Demir
STAR Protocolsno. 2 (2024): 103132-103132
Daniel Schmitz, Emilia Meier,Steffen Axt,Gerrit Arlt, Peter Kienle,Jonas Johannink, Alfred Koenigsrainer, Owais Mohammad,Ralf Jakobs,Stefan Willis,Ihsan Ekin Demir,Helmut Friess,Svetlana Hetjens,Matthias Philip Ebert,Christoph Reissfelder,Georgi Vassilev
ZEITSCHRIFT FUR GASTROENTEROLOGIE (2024)
Naomi D. E. Thierens,Ihsan Ekin Demir
UNITED EUROPEAN GASTROENTEROLOGY JOURNALno. 3 (2024): 281-282
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作者统计
#Papers: 353
#Citation: 5941
H-Index: 47
G-Index: 73
Sociability: 7
Diversity: 3
Activity: 145
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