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My research focuses on the biological drivers for prostate cancer progression and treatment-resistance. The startpoints for these studies are transcriptomic and metabolomic datasets generated in pre-clinical models and clinical samples. Pre-clinical models allow temporal datasets to be generated with control over the genomic background and treatment schedules. This enables adaptive responses to oncogenic and treatment stress to be evaluated. Prostate cancer is a high-incidence male cancer which progresses to metastasis in a subset of cases raising a clear need for improved stratification based on profiling and biological modelling of the disease. The most significant biological contributors to progression are likely to be those that are enriched downstream of a range of genomic drivers or treatment regimes in surviving cancer cells. Examples of this include immune modulatory and DNA damage response pathways that allow cancer cells to acquire genomic instability without succumbing to apoptosis or eliciting an effective immune response in the tumour microenvironment. From a start-point of cancer cell-intrinsic pathways driven by the androgen receptor, and latterly by assessing responses to radiotherapy, we are now seeking to address the role of the unfolded protein response and innate immune signalling in these changes. Selection of most important positive and negative regulators of these processes will require genetic screening, further characterisation of clinical sample collections and the further development and use of immune-competent pre-clinical models. A better understanding of these processes will enable effective repurposing of immune therapies and drugs targeting metabolic processes for the treatment of prostate cancer in the appropriate subsets of patients.
Research Interests
Papers共 422 篇Author StatisticsCo-AuthorSimilar Experts
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Cancer Researchno. 6_Supplement (2024): 4205-4205
Srinivasa Rao,Clare Verrill,Lucia Cerundolo,Nasullah Khalid Alham,Zeynep Kaya, Miriam O’Hanlon,Alicia Hayes,Adam Lambert, Martha James,Iain D. C. Tullis, Jane Niederer, Shelagh Lovell,Altan Omer,Francisco Lopez,Tom Leslie,Francesca Buffa,Richard J. Bryant,Alastair D. Lamb,Boris Vojnovic,David C. Wedge,Ian G. Mills,Dan J. Woodcock,Ian Tomlinson,Freddie C. Hamdy
GENOME MEDICINEno. 1 (2024)
British journal of surgeryno. Supplement_2 (2024)
H. T. Sjoberg, S. Macklin,Y. Philippou,E. A. Murphy,I Tullis, K. Jones,S. Stribbling,D. Preise,L. Agemy, T. Yechezkel, A. Giaccia,I. G. Mills,R. Muschel, B. Vojnovic,A. Scherz,F. C. Hamdy,R. J. Bryant
EUROPEAN UROLOGY (2024): S2204-S2204
Sandy Figiel,Wencheng Yin,Mengxiao He,Renuka Teague,Thineskrishna Anbarasan,Nithesh Ranasinha, Sophia Abusamra,Reema Singh,Dimitrios Doultsinos,Ninu Poulose,Andrew Erickson,Clare Verrill,Richard Colling,Pelvender Gill,Richard J. Bryant,Olivier Cussenot,Massimo Loda,Freddie C. Hamdy,Dan J. Woodcock,Ian G. Mills,Joakim Lundeberg,Alastair D. Lamb
Deborah Y Moss, Connor Brown, Andrew Shaw,Christopher McCann, Nikita Lewis, Aaron Phillips, Sarah Gallagher,William J McDaid,Andrew Roe, Aisling Y Coughlan, Brenton Cavanagh, Callum Ormsby,Fiammetta Falcone, Rachel McCole, Scott Monteith,Emily Rogan, Matilda Downs,Sudhir B Malla, Alexandra J Emerson, Letitia Mohammed-Smith, Shaun Sharkey,Peter F Gallagher, Arindam Banerjee, Sufyan Pandor,Brett Greer,Christopher Elliott,Aideen Ryan, Philip D Dunne,Vicky Coyle,Ian G Mills,Simon S McDade,Owen Sansom,Triona Ni Chonghaile, Daniel B Longley,Melissa J LaBonte,Emma M Kerr
crossref(2024)
CANCER RESEARCHno. 6 (2024)
Charles H. Williams,Leif R. Neitzel,Jessica Cornell,Samantha Rea,Ian Mills, Maya S. Silver, Jovanni D. Ahmad,Konstantin G. Birukov,Anna Birukova,Henry Brem,Betty Tyler,Eli E. Bar,Charles C. Hong
Experimental hematology & oncologyno. 1 (2024): 13-13
Antti Kiviaho,Sini K. Eerola,Heini M.L. Kallio,Maria K. Andersen,Xander Spotbeen,Alexander Giesen, Charles T.A. Parker,Sinja Taavitsainen, Olli Hantula,Mikael Marttinen,Ismaïl Hermelo,Mazlina Ismail,Elise Midtbust, Maximilian Wess,Wout Devlies,Abhibhav Sharma,Sebastian Krossa,Tomi Häkkinen,Ebrahim Afyounian,Juha Kesseli,Teemu Tolonen,Teuvo L.J. Tammela,Trond Viset,Øystein Størkersen,Guro F. Giskeødegård,Morten B. Rye,Teemu Murtola,Andrew Erickson,Leena Latonen,G. Steven Bova,Ian G. Mills,Steven Joniau,Johannes V. Swinnen,Thierry Voet,Tuomas Mirtti, Gerhardt Attard,Frank Claessens,Tapio Visakorpi,Kirsi J. Rautajoki,May-Britt Tessem,Alfonso Urbanucci,Matti Nykter
biorxiv(2024)
Nikita Sushentsev,Gregory Hamm,Lucy Flint, Daniel Birtles, Aleksandr Zakirov,Jack Richings,Stephanie Ling, Jennifer Y. Tan,Mary A. Mclean, Vinay Ayyappan,Ines Horvat Menih,Cara Brodie,Jodi L. Miller,Ian G. Mills,Vincent J. Gnanapragasam,Anne Y. Warren, Simon T. Barry,Richard J. A. Goodwin,Tristan Barrett,Ferdia A. Gallagher
NATURE COMMUNICATIONSno. 1 (2024)
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Author Statistics
#Papers: 427
#Citation: 17502
H-Index: 65
G-Index: 126
Sociability: 8
Diversity: 0
Activity: 4
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