My current interests concern the role of serotonin in the aetiology and treatment of affective disorders and the use of functional brain imaging to investigate emotional processing and neurotransmitter function in depression. I am a co-author of the British Association for Psychopharmacology (BAP) guidelines for treating depressive disorders with antidepressants, and a co-author of the BAP guidelines for treating anxiety disorders. I was Chair of the Clinical Guideline Development Group to update the National Institute for Health and Clinical Excellence treatment guideline for depression (2009).